Characteristics of cardio-Cerebrovascular modulation in patients with generalized anxiety disorder: an observational study.
Characteristics of cardio-Cerebrovascular modulation in patients with generalized anxiety disorder: an observational study.
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广泛性焦虑症患者心脑血管调节的特征：一项观察性研究。
DOI：
10.1186/s12888-017-1428-6
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发表时间：
2017-07-18
期刊：
影响因子：
4.4
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Guo ZN;Feng L;Yan X;Yang L;Huang S;Xing Y;Yang Y
广泛性焦虑症（GAD）在以往的研究中已被证明显示异常的脑血流速度（CBFV），然而，心脑血管调制的特点是未知的。我们的目的是使用仰卧到站立测试的参数分析心脑血管调节。本研究分为2部分;第1部分入组了125名汉密尔顿焦虑量表评分≥14的受试者，招募了33名年龄和性别匹配的医学和精神健康志愿者作为对照受试者。患者按评分分为轻度、中度和重度焦虑组。以立位刺激时CBFV和心率的动态变化为参数，探讨了对心脑血管的调节作用。第二部分对重度广泛性焦虑症患者进行6个月的随访，重复仰卧-站立试验，并将重度广泛性焦虑症患者分为恢复组和未恢复组。在第一部分中，GAD组的CBFV和心率变化比健康组更明显，但在轻度、中度和重度焦虑组中，从仰卧位到直立位的CBFV和心率变化没有差异。在第二部分中，与治疗前相比，恢复组在治疗后从仰卧位到直立位的CBFV和心率值的变化中表现出显著改善。未恢复组中，无论治疗与否，CBFV和心率变化均显著高于健康组。广泛性焦虑障碍患者脑-脑血管调节功能受损，但焦虑消失后，这种损害可恢复正常。本文的在线版本（doi：10.1186/s12888-017-1428-6）包含补充材料，可供授权用户使用。
Generalized anxiety disorder (GAD) has been shown in previous studies to display abnormal cerebral blood flow velocity (CBFV); however, the characteristics of cardio-cerebrovascular modulation are unknown. We aimed to analyze cardio-cerebrovascular modulation using parameters from a supine-to-standing test. There are 2 parts to this study; in Part 1, 125 participants with Hamilton Anxiety scale scores ≥14 were enrolled, and 33 age- and sex-matched medically and psychiatrically healthy volunteers were recruited as control participants. Patients were divided by score into mild, moderate, and severe anxiety groups. The cardio-cerebrovascular modulation using the parameters of dynamic changes of CBFV and heart rate in response to an orthostatic challenge were investigated. In Part 2, we followed up the severe GAD patients for 6 months and repeated the supine-to-standing test, and severe GAD patients were divided into recovery and non-recovery groups. In part 1, the GAD group displayed more marked CBFV and heart rate changes than the healthy group, but there was no difference in the CBFV and heart rate changes from the supine to upright position in mild, moderate, and severe anxiety groups. In part 2, The recovery group demonstrated significant improvement in changes in the CBFV and heart rate values from the supine to the upright position after treatment compared with before treatment. In the non-recovery group, the CBFV and heart rate changes were significantly higher than the healthy group regardless of treatment. Cardio-cerebrovascular modulation is compromised in patients with GAD, however, this impairment can be restored to normal after the disappearance of anxiety. The online version of this article (doi:10.1186/s12888-017-1428-6) contains supplementary material, which is available to authorized users.
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影响因子：
6.9
作者：
Paulesu, E.;Sambugaro, E.;Sassaroli, S.
通讯作者：
Sassaroli, S.
DOI：
10.1016/j.pnpbp.2006.08.004
发表时间：
2007-01-30
影响因子：
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作者：
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4.4
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影响因子：
3.1
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通讯作者：
Wittchen, Hans-Ullrich
影响因子：
10.6
作者：
Makovac, Elena;Meeten, Frances;Ottaviani, Cristina
通讯作者：
Ottaviani, Cristina