A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES).
A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES).
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一项针对非裔美国女性卵巢癌的多中心人群病例对照研究：非裔美国人癌症流行病学研究 (AACES)。
DOI：
10.1186/1471-2407-14-688
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发表时间：
2014-09-22
期刊：
影响因子：
3.8
通讯作者：
Moorman PG
中科院分区：
文献类型：
--
作者：
Schildkraut JM;Alberg AJ;Bandera EV;Barnholtz-Sloan J;Bondy M;Cote ML;Funkhouser E;Peters E;Schwartz AG;Terry P;Wallace K;Akushevich L;Wang F;Crankshaw S;Moorman PG
卵巢癌（OVCA）是妇科癌症死亡的主要原因，与白人相比，非洲裔美国人（AA）妇女的生存率更低。然而，对AA中OVCA的危险因素知之甚少。为了研究OVCA在这一人群中的流行病学，我们在美国的10个地点开始了合作努力。在这里，我们描述了这项研究，并强调了在少数群体中进行致命疾病研究的挑战。非裔美国人癌症流行病学研究（AACES）是一项正在进行的、基于人群的病例对照研究，在10个地理位置对AA中的OVCA进行研究，旨在招募850名侵袭性上皮OVCA女性和850名年龄和地理位置与病例匹配的对照。已建立了快速病例确定和随机数字拨号系统，分别用于确定病例和控制。电话调查的重点是风险因素以及与AA特别相关的因素。还获得了食物频率问卷、后续调查、生物标本和医疗记录。目前累积的403例AA OVCA病例和639例对照超过了迄今为止任何现有的研究。我们观察到在这些病例中死亡的无应答者比例很高（15%），部分原因是诊断时的晚期。Logistic回归模型不支持社会经济地位是诊断时晚期的一个因素。大多数风险因素的关联在预期的方向和程度。高BMI与卵巢癌风险相关，与正常/体重不足女性相比，肥胖女性的多变量校正OR和95%CI为1.50（0.99-2.27），病态肥胖女性为1.27（0.85- 1.91）。AACES靶向AA中的罕见肿瘤，并解决与该人群最相关的问题。这项研究的重要性由于被确定死亡的卵巢癌病例比例很高而更加突出。我们的分析表明，肥胖，在这一人群中非常普遍（>60%的病例），与OVCA风险增加有关。虽然这些发现需要复制，但它们表明了对AA风险进行有效干预的潜力。入组完成后，AACES将成为AA女性中最大的OVCA流行病学研究。
Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little is known about risk factors for OVCA in AA. To study the epidemiology of OVCA in this population, we started a collaborative effort in 10 sites in the US. Here we describe the study and highlight the challenges of conducting a study of a lethal disease in a minority population. The African American Cancer Epidemiology Study (AACES) is an ongoing, population-based case–control study of OVCA in AA in 10 geographic locations, aiming to recruit 850 women with invasive epithelial OVCA and 850 controls age- and geographically-matched to cases. Rapid case ascertainment and random-digit-dialing systems are in place to ascertain cases and controls, respectively. A telephone survey focuses on risk factors as well as factors of particular relevance for AAs. Food-frequency questionnaires, follow-up surveys, biospecimens and medical records are also obtained. Current accrual of 403 AA OVCA cases and 639 controls exceeds that of any existing study to date. We observed a high proportion (15%) of deceased non-responders among the cases that in part is explained by advanced stage at diagnosis. A logistic regression model did not support that socio-economic status was a factor in advanced stage at diagnosis. Most risk factor associations were in the expected direction and magnitude. High BMI was associated with ovarian cancer risk, with multivariable adjusted ORs and 95% CIs of 1.50 (0.99-2.27) for obese and 1.27 (0.85- 1.91) for morbidly obese women compared to normal/underweight women. AACES targets a rare tumor in AAs and addresses issues most relevant to this population. The importance of the study is accentuated by the high proportion of OVCA cases ascertained as deceased. Our analyses indicated that obesity, highly prevalent in this population (>60% of the cases), was associated with increased OVCA risk. While these findings need to be replicated, they suggest the potential for an effective intervention on the risk in AAs. Upon completion of enrollment, AACES will be the largest epidemiologic study of OVCA in AA women.
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影响因子：
5.4
作者：
Ness, RB;Grisso, JA;Schlesselman, JJ
通讯作者：
Schlesselman, JJ
影响因子：
5
作者：
Moorman, Patricia G.;Palmieri, Rachel T.;Schildkraut, Joellen M.
通讯作者：
Schildkraut, Joellen M.
影响因子：
6.2
作者：
Barnholtz-Sloan, JS;Tainsky, MA;Schwartz, AG
通讯作者：
Schwartz, AG
影响因子：
6.2
作者：
Farley, John H.;Tian, Chunqiao;Maxwell, G. Larry
通讯作者：
Maxwell, G. Larry
影响因子：
2.1
作者：
SCHILDKRAUT, JM;THOMPSON, WD
通讯作者：
THOMPSON, WD