A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22).
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22).
复制标题
与 inv(16)(p13q22) 相关的急性粒单核细胞白血病中枢神经系统白血病的独特模式。
作者：
R. Holmes;M. Keating;A. Cork;Y. Broach;J. Trujillo;W. Dalton;K. McCredie;E. Freireich
Twenty-six patients with inv(16)(p13q22) or del(16)(q22) in association with acute myelomonocytic leukemia (AMML-M4, FAB classification), and abnormal marrow eosinophils have been treated at this institute. Initial bone marrow eosinophilia (greater than or equal to 4%) was observed in 22 of 26 patients (85%), and abnormal eosinophil morphology, characterized by immature cells with some interspersed basophilic granules, was evident in 26 of 26 (100%). Giemsa-banded chromosome analysis performed in all patients revealed 16 cases with inv(16)(p13q22) alone, and ten cases with additional chromosome changes. Twenty-five patients received combination induction chemotherapy, and 23 (92%) achieved complete remission (CR). The median duration of remission was 18 months (range, six to 72 + months), and the median duration of survival was 34 months (range, 0.5 to 133 months). Nine patients (35%) relapsed in the CNS at a median time of 19 months (range, six to 133 months) from first marrow CR. All patients had leptomeningeal disease, and in addition, six of nine (66%) demonstrated two or more enhancing lesions on computed tomography brain scan, consistent with intracerebral myeloblastomas. Review of 384 Giemsa-banded patients with acute myeloid leukemia revealed no other morphologic or cytogenetic subgroup with either an equivalent incidence of CNS leukemia or documented intracerebral myeloblastomas. This series of inv(16)(p13q22)/del(16)(q22) AMML reports a favorable prognosis for such patients and associates a specific clonal cytogenetic subgroup of acute leukemia with a distinct propensity for CNS relapse, manifesting as leptomeningeal disease and intracerebral myeloblastomas.
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影响因子：
158.5
作者：
LEBEAU, MM;LARSON, RA;ROWLEY, JD
通讯作者：
ROWLEY, JD
DOI：
10.1056/nejm198107163050304
发表时间：
1981-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Yunis;C. Bloomfield;K. Ensrud
通讯作者：
J. Yunis;C. Bloomfield;K. Ensrud
第四届白血病染色体国际研讨会：急性非淋巴细胞白血病的前瞻性研究。
影响因子：
--
作者：
通讯作者：
--
癌症转移中的肿瘤细胞多样性和宿主反应——第二部分——宿主免疫反应和转移治疗。
影响因子：
2.6
作者：
Nicolson,GL;Poste,G
通讯作者：
Poste,G
影响因子：
15.9
作者：
WASSOM, DL;LOEGERING, DA;GLEICH, GJ
通讯作者：
GLEICH, GJ