Association between 25-hydroxyvitamin D levels and COVID-19 severity.
Association between 25-hydroxyvitamin D levels and COVID-19 severity.
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DOI：
10.1016/j.clnesp.2022.04.003
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发表时间：
2022-06
影响因子：
3
通讯作者：
Muroi N
中科院分区：
文献类型：
--
作者：
Takase T;Tsugawa N;Sugiyama T;Ikesue H;Eto M;Hashida T;Tomii K;Muroi N
尽管有关于维生素D状态对2019年冠状病毒病(新冠肺炎)严重程度影响的报道，但维生素D水平低与严重新冠肺炎之间的关联仍不清楚。此外，研究人员还没有在日本患者中确定上述关联。本研究旨在调查日本患者中25-羟基维生素D[25(OH)D]水平与新冠肺炎严重程度的关系。这项回顾性观察研究包括2020年10月1日至2021年1月31日神户市医学中心总医院收治的117名新冠肺炎患者。入院后5天内采集血液标本，用高效液相色谱-串联质谱仪测定血清25(OH)D水平。维生素D严重缺乏21例(17.9%)，维生素D缺乏73例(62.4%)，维生素D缺乏19例(16.2%)，维生素D缺乏4例(3.4%)，维生素D缺乏20例(17.9%)，维生素D不足73例(62.4%)，≥不足4例(3.4%)。单因素Logistic回归分析显示，血清25(OH)D水平降低[优势比(OR)1.18/1 ng/m L下降，95%可信区间(CI)1.04~1.33，P=0.007]与有创机械通气或死亡显著相关。多因素Logistic回归分析显示，低血清25(OH)D水平[OR1.22/1 ng/m L下降，95%可信区间1.06~1.40，P=0.005]与IMV或死亡显著相关。血清25(OH)D水平的界值为10.4 ng/mL，根据受试者的工作特征曲线计算，以判断是否需要IMV或死亡。据我们所知，这是第一项评估日本患者维生素D状况和新冠肺炎严重程度之间关系的研究。在日本患者中，低血清25(OH)D水平被检测为严重新冠肺炎的独立危险因素。
Despite reports on the impact of vitamin D status on coronavirus disease 2019 (COVID-19) severity, the association between low vitamin D status and severe COVID-19 remains unclear. Moreover, researchers have not determined the aforementioned association in Japanese patients. This study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] levels and COVID-19 severity in Japanese patients. This retrospective observational study included 117 consecutive patients with COVID-19 admitted to the Kobe City Medical Center General Hospital between October 01, 2020, and January 31, 2021. We measured the serum 25(OH)D levels using blood specimens collected within 5 days of hospital admission using liquid chromatography-tandem mass spectrometry. There were 21 (17.9%), 73 (62.4%), 19 (16.2%) and 4 (3.4%) patients with severe deficiency (<10 ng/mL), deficiency (10–<20 ng/mL), insufficiency (20–<30 ng/mL), and sufficiency (≥30 ng/mL) of vitamin D, respectively. In univariate logistic regression analyses, lower serum 25(OH)D levels [odds ratio (OR) 1.18 per 1 ng/mL decrease, 95% confidence interval (CI) 1.04–1.33, p = 0.007] were significantly associated with invasive mechanical ventilation (IMV) or death. In a multivariate logistic regression analysis, low serum 25(OH)D levels [OR 1.22 per 1 ng/mL decrease, 95% CI 1.06–1.40, p = 0.005] were significantly associated with IMV or death. The cut-off value of serum 25(OH)D levels was 10.4 ng/mL, calculated by the receiver operating characteristic curve to detect the requirement for IMV or death. To the best of our knowledge, this is the first study to assess the association between vitamin D status and COVID-19 severity in Japanese patients. Low serum 25(OH)D level was detected as an independent risk factor for severe COVID-19 among Japanese patients.
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影响因子：
3.7
作者：
Davoudi A;Najafi N;Aarabi M;Tayebi A;Nikaeen R;Izadyar H;Salar Z;Delavarian L;Vaseghi N;Daftarian Z;Ahangarkani F
通讯作者：
Ahangarkani F
影响因子：
3.5
作者：
De Smet, Dieter;De Smet, Kristof;Martens, Geert A.
通讯作者：
Martens, Geert A.
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.1136/bmj.i6583
发表时间：
2017-02-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Martineau AR;Jolliffe DA;Hooper RL;Greenberg L;Aloia JF;Bergman P;Dubnov-Raz G;Esposito S;Ganmaa D;Ginde AA;Goodall EC;Grant CC;Griffiths CJ;Janssens W;Laaksi I;Manaseki-Holland S;Mauger D;Murdoch DR;Neale R;Rees JR;Simpson S Jr;Stelmach I;Kumar GT;Urashima M;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
5.9
作者：
Karonova TL;Andreeva AT;Golovatuk KA;Bykova ES;Simanenkova AV;Vashukova MA;Grant WB;Shlyakhto EV
通讯作者：
Shlyakhto EV