Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19.
Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19.
复制标题
DOI：
10.3390/nu13093021
复制
发表时间：
2021-08-29
期刊：
影响因子：
5.9
通讯作者：
Shlyakhto EV
中科院分区：
文献类型：
--
作者：
Karonova TL;Andreeva AT;Golovatuk KA;Bykova ES;Simanenkova AV;Vashukova MA;Grant WB;Shlyakhto EV
我们评估了住院患者血清25-羟基维生素D[25(OH)D]水平与新冠状病毒感染(新冠肺炎)严重程度的相关性。我们测定了133例年龄在21-93岁的患者的血清25(OH)D水平。重症25例(19%)，中度108例(81%)，死亡18例(14%)。25(OH)D水平范围为3.0~97.0 ng/mL(中位数13.5[25%；75%，9.6；23.3]ng/mL)。90例患者被诊断为维生素D缺乏症，其中37例为严重缺乏症。在病程较重的患者中，25(OH)D水平较低(中位数9.7[25%；75%，6.0；14.9]ng/mL)，维生素D缺乏症较中病程患者更常见(中位数14.6[25%；75%，10.6；24.4]ng/mL，p=0.003)。在死亡患者中，25(OH)D为9.6[25%；75%，6.0；11.5]ng/mL，而出院患者为14.8[25%；75%，10.1；24.3]ng/mL(p=0.001)。严重的维生素D缺乏与新冠肺炎严重程度和致命结局的风险增加相关。25(OH)D水平与严重病程风险增加相关的阈值为11.7 ng/mL。大致相同的25(OH)D水平，10.9 ng/ml，与死亡风险增加有关。因此，大多数新冠肺炎患者都缺乏维生素D；严重的维生素D缺乏与新冠肺炎严重程度和致命结局的风险增加相关。
We evaluated associations between serum 25-hydroxyvitamin D [25(OH)D] level and severity of new coronavirus infection (COVID-19) in hospitalized patients. We assessed serum 25(OH)D level in 133 patients aged 21–93 years. Twenty-five (19%) patients had severe disease, 108 patients (81%) had moderate disease, and 18 (14%) patients died. 25(OH)D level ranged from 3.0 to 97.0 ng/mL (median, 13.5 [25%; 75%, 9.6; 23.3] ng/mL). Vitamin D deficiency was diagnosed in 90 patients, including 37 with severe deficiency. In patients with severe course of disease, 25(OH)D level was lower (median, 9.7 [25%; 75%, 6.0; 14.9] ng/mL), and vitamin D deficiency was more common than in patients with moderate course (median, 14.6 [25%; 75%, 10.6; 24.4] ng/mL, p = 0.003). In patients who died, 25(OH)D was 9.6 [25%; 75%, 6.0; 11.5] ng/mL, compared with 14.8 [25%; 75%, 10.1; 24.3] ng/mL in discharged patients (p = 0.001). Severe vitamin D deficiency was associated with increased risk of COVID-19 severity and fatal outcome. The threshold for 25(OH)D level associated with increased risk of severe course was 11.7 ng/mL. Approximately the same 25(OH)D level, 10.9 ng/mL, was associated with increased risk of mortality. Thus, most COVID-19 patients have vitamin D deficiency; severe vitamin D deficiency is associated with increased risk of COVID-19 severity and fatal outcome.
登录
查看更多内容
影响因子：
5.9
作者：
Fakhoury HMA;Kvietys PR;Shakir I;Shams H;Grant WB;Alkattan K
通讯作者：
Alkattan K
DOI：
10.1016/j.jsbmb.2016.03.026
发表时间：
2016-11-01
影响因子：
4.1
作者：
Karonova, T.;Andreeva, A.;Grineva, E.
通讯作者：
Grineva, E.
DOI：
10.1016/j.jcte.2016.04.004
发表时间：
2016-06-01
影响因子：
3
作者：
Han, Jenny E.;Jones, Jennifer L.;Martin, Greg S.
通讯作者：
Martin, Greg S.
影响因子：
4.3
作者：
Chua, Marvin Wei Jie;Zheng, Shuwei
通讯作者：
Zheng, Shuwei
影响因子：
--
作者：
HOPESIMPSON, RE
通讯作者：
HOPESIMPSON, RE