Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection.
Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection.
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DOI：
10.1186/s12879-021-06168-7
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发表时间：
2021-05-18
影响因子：
3.7
通讯作者：
Ahangarkani F
中科院分区：
文献类型：
--
作者：
Davoudi A;Najafi N;Aarabi M;Tayebi A;Nikaeen R;Izadyar H;Salar Z;Delavarian L;Vaseghi N;Daftarian Z;Ahangarkani F
维生素D对新冠肺炎感染的保护作用正在研究中。我们的目的是分析维生素D充足对新冠肺炎感染患者临床结局的影响。在这项横断面研究中，我们分析了2020年2月至3月在拉齐医院(伊朗北部马赞达兰省的传染病转送中心)住院的新冠肺炎患者的维生素D水平。总体而言，使用30 ng/mL的截断点来定义维生素D的充分性。这项研究分析了153名住院时有25(OH)D水平的实验室记录的患者。患者维生素D水平为27.19 ± 20.17 ng/mL。总体而言，62.7%(n = 96)患者的25(OH)D水平低于30 ng/m L，37.25%(n = 57)患者的25(OH)D水平大于30 ng/m L。总体而言，49%(n = 75)的患者至少患有一种潜在疾病。单因素和多变量回归分析显示，维生素D充足与新冠肺炎不良临床结局的风险(如住院时间和感染严重程度)在统计学上没有显著相关性(P >； 0.05)。研究发现，在感染新冠肺炎的患者中，充足的维生素D水平并不能预防不良的临床结果。新冠肺炎患者的慢性疾病被发现在决定感染的不良结果方面比维生素D水平具有更大的相关性。需要进一步的研究来确定维生素D水平在预测新冠肺炎感染结局中的作用。
A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection.
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影响因子：
3.7
作者：
Maghbooli Z;Sahraian MA;Ebrahimi M;Pazoki M;Kafan S;Tabriz HM;Hadadi A;Montazeri M;Nasiri M;Shirvani A;Holick MF
通讯作者：
Holick MF
DOI：
10.1016/j.dsx.2020.04.050
发表时间：
2020-07-01
影响因子：
10
作者：
Hastie, Claire E.;Mackay, Daniel F.;Pell, Jill P.
通讯作者：
Pell, Jill P.
影响因子：
4.6
作者：
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通讯作者：
Budhiraja S
影响因子：
158.5
作者：
Guan, W.;Ni, Z.;Zhong, N.
通讯作者：
Zhong, N.
影响因子：
4
作者：
Ilie, Petre Cristian;Stefanescu, Simina;Smith, Lee
通讯作者：
Smith, Lee