Comparison of cochlear morphology and apoptosis in mouse models of presbycusis.
Comparison of cochlear morphology and apoptosis in mouse models of presbycusis.
复制标题
DOI：
10.3342/ceo.2010.3.3.126
复制
发表时间：
2010-09
影响因子：
3
通讯作者：
Yeo SW
中科院分区：
文献类型：
--
作者：
Park SN;Back SA;Park KH;Kim DK;Park SY;Oh JH;Park YS;Yeo SW
对老年性耳聋（即年龄相关性听力损失）的形态学研究已在几种表现出伴有听觉病理的听力损失的不同品系小鼠中进行。C57BL/6（C57）小鼠是早发性老年性耳聋的已知模型，而CBA小鼠的特点是听力损失相对较晚发生。我们进行这项研究是为了进一步了解早发性听力损失与耳蜗衰老过程的关系。
我们将C57耳蜗病理及其伴随的凋亡过程与CBA小鼠的进行了比较。通过听性脑干反应（ABR）记录和畸变产物耳声发射（DPOAE）评估了听力阈值和外毛细胞功能。
ABR记录和DPOAE研究表明，C57小鼠在3月龄时出现高频听力损失。对1月龄的C57和CBA小鼠的耳蜗形态学研究未显示出柯蒂氏器、螺旋神经节或血管纹存在差异。然而，从3月龄及以后观察到，与CBA小鼠相比，C57小鼠在耳蜗基底回出现明显的早期外毛细胞退变，而螺旋神经节细胞和血管纹/螺旋韧带没有明确的退变。此外，C57小鼠的凋亡过程也显示出更早的进展。
这些数据表明，C57小鼠在其幼年直至6月龄时可能是早发性“感觉性”老年性耳聋的极佳动物模型。进一步研究导致C57小鼠柯蒂氏器（尤其是高频区域）早期退变的内在或外在病因因素，可能会提供早发性听力损失的一种可能病理机制。
Morphological studies on presbycusis, or age-related hearing loss, have been performed in several different strains of mice that demonstrate hearing loss with auditory pathology. The C57BL/6 (C57) mouse is a known model of early onset presbycusis, while the CBA mouse is characterized by relatively late onset hearing loss. We performed this study to further understand how early onset hearing loss is related with the aging process of the cochlea. We compared C57 cochlear pathology and its accompanying apoptotic processes to those in CBA mice. Hearing thresholds and outer hair cell functions have been evaluated by auditory brainstem response (ABR) recordings and distortion product otoacoustic emission (DPOAE). ABR recordings and DPOAE studies demonstrated high frequency hearing loss in C57 mice at P3mo of age. Cochlear morphologic studies of P1mo C57 and CBA mice did not show differences in the organ of Corti, spiral ganglion, or stria vascularis. However, from P3mo and onwards, a predominant early outer hair cell degeneration at the basal turn of the cochlea in C57 mice without definitive degeneration of spiral ganglion cells and stria vascularis/spiral ligament, compared with CBA mice, was observed. Additionally, apoptotic processes in the C57 mice also demonstrated an earlier progression. These data suggest that the C57 mouse could be an excellent animal model for early onset 'sensory' presbycusis in their young age until P6mo. Further studies to investigate the intrinsic or extrinsic etiologic factors that lead to the early degeneration of organ of Corti, especially in the high frequency region, in C57 mice may provide a possible pathological mechanism of early onset hearing loss.
登录
查看更多内容
影响因子：
2.4
作者：
Spongr, VP;Flood, DG;Salvi, RJ
通讯作者：
Salvi, RJ
影响因子：
2.8
作者：
Ichimiya, I;Suzuki, M;Mogi, G
通讯作者：
Mogi, G
DOI：
10.1007/bf02103767
发表时间：
1960-01-01
期刊：
Archiv fur Ohren-, Nasen- und Kehlkopfheilkunde
影响因子：
--
作者：
KOCHER, W
通讯作者：
KOCHER, W
影响因子：
2.8
作者：
Sha, Su-Hua;Chen, Fu-Quan;Schacht, Jochen
通讯作者：
Schacht, Jochen
影响因子：
1.4
作者：
LI, HS;BORG, E
通讯作者：
BORG, E