Modulation of feedback-related negativity during trial-and-error exploration and encoding of behavioral shifts.
Modulation of feedback-related negativity during trial-and-error exploration and encoding of behavioral shifts.
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DOI：
10.3389/fnins.2013.00209
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发表时间：
2013
影响因子：
4.3
通讯作者：
Procyk E
中科院分区：
文献类型：
--
作者：
Sallet J;Camille N;Procyk E
反馈相关负波（FRN）是在各种认知任务中记录的额叶中部事件相关电位（ERP），与感觉反馈信号决策结果的发生有关。FRN的一些属性仍然存在争议，特别是它对积极和消极奖励预测误差（RPE）的敏感性-即，特定反馈的预期和实际发生之间的差异，以及它在触发反馈后调整中的作用。在本研究中，我们测试了FRN是否受到正性和负性RPE的调节。我们还测试了是否指示线索，表明需要行为调整引起的FRN。我们要求12名人类受试者执行一项解决问题的任务，他们必须通过试验和错误来搜索屏幕上呈现的五个视觉目标中的哪一个与正确的反馈相关。在探索和发现正确的目标之后，受试者可以重复他们的正确选择，直到指示新搜索的视觉信号改变（SC）的开始。分析表明，负预测误差（RPE）和正预测误差（RPE）都对FRN有调制作用。最后，我们发现，SC引起的额叶中线电极上的FRN样电位不调制的事件的概率。总的来说，这些结果表明，FRN可能反映了一种机制，评估任何事件（结果，指令提示）信号需要从事自适应行动。
The feedback-related negativity (FRN) is a mid-frontal event-related potential (ERP) recorded in various cognitive tasks and associated with the onset of sensory feedback signaling decision outcome. Some properties of the FRN are still debated, notably its sensitivity to positive and negative reward prediction error (RPE)—i.e., the discrepancy between the expectation and the actual occurrence of a particular feedback,—and its role in triggering the post-feedback adjustment. In the present study we tested whether the FRN is modulated by both positive and negative RPE. We also tested whether an instruction cue indicating the need for behavioral adjustment elicited the FRN. We asked 12 human subjects to perform a problem-solving task where they had to search by trial and error which of five visual targets, presented on a screen, was associated with a correct feedback. After exploration and discovery of the correct target, subjects could repeat their correct choice until the onset of a visual signal to change (SC) indicative of a new search. Analyses showed that the FRN was modulated by both negative and positive prediction error (RPE). Finally, we found that the SC elicited an FRN-like potential on the frontal midline electrodes that was not modulated by the probability of that event. Collectively, these results suggest the FRN may reflect a mechanism that evaluates any event (outcome, instruction cue) signaling the need to engage adaptive actions.
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DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
3.7
作者：
Beste, Christian;Saft, Carsten;Falkenstein, Michael
通讯作者：
Falkenstein, Michael
影响因子：
2.9
作者：
de Bruijn, Ellen R. A.;Sabbe, Bernard G. C.;Verkes, Robbert J.
通讯作者：
Verkes, Robbert J.
影响因子：
56.9
作者：
Gehring, WJ;Willoughby, AR
通讯作者：
Willoughby, AR
影响因子：
5.3
作者：
Ferdinand, Nicola K.;Mecklinger, Axel;Gehring, William J.
通讯作者：
Gehring, William J.