High-intensity sweeteners and energy balance.
High-intensity sweeteners and energy balance.
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DOI：
10.1016/j.physbeh.2009.12.021
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发表时间：
2010-04-26
影响因子：
2.9
通讯作者：
Davidson, Terry L.
中科院分区：
文献类型：
--
作者：
Swithers, Susan E.;Martin, Ashley A.;Davidson, Terry L.
最近的流行病学证据表明，各种负面健康结果（如代谢综合征、糖尿病和心血管疾病）与饮用含热量饮料和含高强度无热量甜味剂的饮料之间存在联系。关于非营养性甜味剂促进食物摄入、体重增加和代谢紊乱的可能性的研究，由于缺乏描述这些结果的机制基础的生理相关模型而受到阻碍。我们已经提出，基于巴甫洛夫条件反射原理，食用非营养性甜味剂可能导致甜味不再作为营养摄入后后果的一致预测因素。甜味线索和热量后果之间的这种分离可能导致甜味唤起调节能量平衡的生理反应的能力下降。通过啮齿类动物模型，我们发现，与摄入含有葡萄糖的食物和液体相比，摄入含有非营养性甜味剂的食物或液体会导致食物摄入量增加、体重增加、体脂肪积累和较弱的热量补偿。我们的研究也提供了与假设一致的证据，即摄入糖精的这些影响可能与甜味引起热反应的能力下降有关，也可能与其他被认为有助于维持能量平衡的生理，头期反射有关。
Recent epidemiological evidence points to a link between a variety of negative health outcomes (e.g. metabolic syndrome, diabetes and cardiovascular disease) and the consumption of both calorically sweetened beverages and beverages sweetened with high-intensity, non-caloric sweeteners. Research on the possibility that non-nutritive sweeteners promote food intake, body weight gain, and metabolic disorders has been hindered by the lack of a physiologically-relevant model that describes the mechanistic basis for these outcomes. We have suggested that based on Pavlovian conditioning principles, consumption of non-nutritive sweeteners could result in sweet tastes no longer serving as consistent predictors of nutritive postingestive consequences. This dissociation between the sweet taste cues and the caloric consequences could lead to a decrease in the ability of sweet tastes to evoke physiological responses that serve to regulate energy balance. Using a rodent model, we have found that intake of foods or fluids containing non-nutritive sweeteners was accompanied by increased food intake, body weight gain, accumulation of body fat, and weaker caloric compensation, compared to consumption of foods and fluids containing glucose. Our research also provided evidence consistent with the hypothesis that these effects of consuming saccharin may be associated with a decrement in the ability of sweet taste to evoke thermic responses, and perhaps other physiological, cephalic phase, reflexes that are thought to help maintain energy balance.
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影响因子：
1.9
作者：
Swithers, Susan E.;Baker, Chelsea R.;Davidson, T. L.
通讯作者：
Davidson, T. L.
影响因子：
--
作者：
DIAMOND, P;BRONDEL, L;LEBLANC, J
通讯作者：
LEBLANC, J
影响因子：
--
作者：
LEBLANC, J;CABANAC, M;SAMSON, P
通讯作者：
SAMSON, P
影响因子：
37.8
作者：
Lutsey, Pamela L.;Steffen, Lyn M.;Stevens, June
通讯作者：
Stevens, June
影响因子：
7.1
作者：
Nettleton, Jennifer A.;Polak, Joseph F.;Jacobs, David R., Jr.
通讯作者：
Jacobs, David R., Jr.