Effects of heavy prenatal alcohol exposure and iron deficiency anemia on child growth and body composition through age 9 years.
Effects of heavy prenatal alcohol exposure and iron deficiency anemia on child growth and body composition through age 9 years.
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DOI：
10.1111/j.1530-0277.2012.01810.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Duggan C
中科院分区：
文献类型：
--
作者：
Carter RC;Jacobson JL;Molteno CD;Jiang H;Meintjes EM;Jacobson SW;Duggan C
产前酒精暴露与出生前和出生后的生长受限有关，但人们对这种限制在整个童年时期的自然历史或产前酒精对身体成分的影响知之甚少。探讨胎儿期重度酒精暴露对胎儿纵向生长和体成分的影响。在南非开普敦一家城市产科诊所开始产前护理时，招募了85名重度饮酒孕妇(≥2杯/天或≥4杯/次)和63名戒酒和少量饮酒的对照组(<；1杯/天，不酗酒)，并在怀孕期间就酒精、吸烟、药物使用和人口统计学问题进行了前瞻性访谈。在他们的孩子中，分别在6.5个月和12个月以及5岁和9岁时测量了身长/身高、体重和头围。使用生物电阻抗分析在9岁时估计体脂百分比。在重复测量(调整混杂因素)的多元回归模型中，重度酒精暴露与体重(0.6SD)、身长/身高(0.5SD)和头围(0.9厘米)的减少有关，这些减少主要是在出生时就确定的。这些影响因婴儿期缺铁而加剧，但在5岁时未因缺铁或粮食安全措施而改变。与酒精有关的出生后体重增加延迟在12个月时出现。对头围的影响在9岁时比其他年龄段更大。虽然重度酒精暴露与身体成分的改变无关，但胎儿酒精综合征(Fas)和部分Fas(PFAS)儿童的体脂百分比低于重度接触非综合征儿童和对照组儿童。出生前大量饮酒与持续到9岁的产前生长受限以及婴儿时期体重增加的额外延迟有关。Fas和PFAS的诊断与儿童后期较瘦的身体成分有关。
Prenatal alcohol exposure has been associated with pre- and postnatal growth restriction, but little is known about the natural history of this restriction throughout childhood or the effects of prenatal alcohol on body composition. To examine the effects of heavy prenatal alcohol exposure on longitudinal growth and body composition. 85 heavy drinking pregnant women (≥ 2 drinks/day or ≥ 4 drinks/occasion) and 63 abstaining and light-drinking controls (< 1 drink/day, no binging) were recruited at initiation of prenatal care in an urban obstetrical clinic in Cape Town, South Africa, and prospectively interviewed during pregnancy about alcohol, smoking, drug use, and demographics. Among their children, length/height, weight, and head circumference were measured at 6.5 and 12 months and at 5 and 9 years. Percent body fat was estimated at age 9 years using bioelectric impedance analysis. In multiple regression models with repeated measures (adjusted for confounders), heavy alcohol exposure was associated with reductions in weight (0.6 SD), length/height (0.5 SD), and head circumference (0.9 cm) from 6.5 months to 9 years that were largely determined at birth. These effects were exacerbated by iron deficiency in infancy but were not modified by iron deficiency or measures of food security at 5 years. An alcohol-related postnatal delay in weight gain was seen at 12 months. Effects on head circumference were greater at age 9 than at other age points. Although heavy alcohol exposure was not associated with changes in body composition, children with fetal alcohol syndrome (FAS) and partial FAS (PFAS) had lower % body fat than heavy exposed nonsyndromal and control children. Heavy prenatal alcohol exposure is related to prenatal growth restriction that persists through age 9 years and an additional delay in weight gain during infancy. FAS and PFAS diagnoses are associated with leaner body composition in later childhood.
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DOI：
10.15288/jsa.1975.36.1154
发表时间：
1975-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
BOWMAN, RS;STEIN, LI;NEWTON, JR
通讯作者：
NEWTON, JR
影响因子：
8
作者：
Carter, R. Colin;Jacobson, Sandra W.;Jacobson, Joseph L.
通讯作者：
Jacobson, Joseph L.
影响因子：
5.1
作者：
JACOBSON, JL;JACOBSON, SW;SHANKARAN, S
通讯作者：
SHANKARAN, S
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
3.7
作者：
Liu Y;Balaraman Y;Wang G;Nephew KP;Zhou FC
通讯作者：
Zhou FC