Altered spontaneous brain activity in patients with Parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the prefrontal-limbic system.
Altered spontaneous brain activity in patients with Parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the prefrontal-limbic system.
复制标题
DOI：
10.1371/journal.pone.0084705
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cheng O
中科院分区：
文献类型：
--
作者：
Sheng K;Fang W;Su M;Li R;Zou D;Han Y;Wang X;Cheng O
由于帕金森病 (PD) 患者合并抑郁症的风险很高，因此推测这两种疾病具有共同的致病途径。使用区域同质性 (ReHo) 和功能连接方法，我们表征了静息状态下的人类区域大脑活动，以检查 PD 患者以及 PD 和抑郁症 (PDD) 患者的特定大脑网络。这项研究包括 41 名 PD 人类受试者和 25 名正常人类受试者。患者完成了汉密尔顿抑郁评定量表，并进一步分为两组：有抑郁症状的患者和非抑郁PD患者（nD-PD）。与非抑郁患者相比，有抑郁症状的患者左侧额中回和右侧额下回的区域活动显着增加，左侧杏仁核和双侧舌回的ReHo降低。大脑网络连接分析显示，与 nD-PD 组相比，PDD 患者前额叶边缘系统内的功能连接减少，前额皮质和舌回的功能连接增加。总之，研究结果显示 PDD 患者的区域大脑活动发生改变，情绪调节网络受到破坏。 PDD的发病机制可能归因于多个大脑区域的神经活动异常。
As patients with Parkinson’s disease (PD) are at high risk for comorbid depression, it is hypothesized that these two diseases are sharing common pathogenic pathways. Using regional homogeneity (ReHo) and functional connectivity approaches, we characterized human regional brain activity at resting state to examine specific brain networks in patients with PD and those with PD and depression (PDD). This study comprised 41 PD human patients and 25 normal human subjects. The patients completed the Hamilton Depression Rating Scale and were further divided into two groups: patients with depressive symptoms and non-depressed PD patients (nD-PD). Compared with the non-depressed patients, those with depressive symptoms exhibited significantly increased regional activity in the left middle frontal gyrus and right inferior frontal gyrus, and decreased ReHo in the left amygdala and bilateral lingual gyrus. Brain network connectivity analysis revealed decreased functional connectivity within the prefrontal-limbic system and increased functional connectivity in the prefrontal cortex and lingual gyrus in PDD compared with the nD-PD group. In summary, the findings showed regional brain activity alterations and disruption of the mood regulation network in PDD patients. The pathogenesis of PDD may be attributed to abnormal neural activity in multiple brain regions.
登录
查看更多内容
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
影响因子：
5.7
作者：
Baudrexel, Simon;Witte, Torsten;Hilker, Ruediger
通讯作者：
Hilker, Ruediger
影响因子：
5.7
作者：
Cardoso, Ellison Fernando;Maia, Fernanda Martins;Amaro, Edson, Jr.
通讯作者：
Amaro, Edson, Jr.
静息状态下的大脑网络与同性恋男性性偏好的关联：区域同质性和功能连接性的研究
影响因子：
3.7
作者：
Hu S;Xu D;Peterson BS;Wang Q;He X;Hu J;Xu X;Wei N;Long D;Huang M;Zhou W;Xu W;Zhang M;Xu Y
通讯作者：
Xu Y
影响因子：
3.7
作者：
Cant, Jonathan S.;Goodale, Melvyn A.
通讯作者：
Goodale, Melvyn A.