Assessment of 1/f noise associated with nanopores fabricated through chemically tuned controlled dielectric breakdown.
Assessment of 1/f noise associated with nanopores fabricated through chemically tuned controlled dielectric breakdown.
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DOI：
10.1002/elps.202000285
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发表时间：
2021-04
期刊：
影响因子：
2.9
通讯作者：
Kim MJ
中科院分区：
文献类型：
--
作者：
Saharia J;Bandara YMNDY;Karawdeniya BI;Alexandrakis G;Kim MJ
最近，我们开发了一种制造方法——化学调节控制介电击穿（CT-CDB）——可以产生纳米孔（通过氮化硅薄膜），克服了与固态纳米孔（SSN）相关的传统缺陷。然而，CT-CDB 纳米孔的噪声特性很大程度上尚未被探索。在这项工作中，我们研究了不同溶液 pH、电解质类型、电解质浓度、施加电压和孔径的 CT-CDB 纳米孔的 1/f 噪声。我们的研究结果表明，体 Hooge 参数 (αs) 比透射电子显微镜 (TEM) 制造的 SSN 大一个数量级，而表面 Hooge 参数 (αb) 大约 3 个数量级。 CT-CDB 纳米孔的 αs 比 αb 大约 5 个数量级，这表明表面贡献在 1/f 噪声中起主导作用。 DNA 实验显示捕获率随着 pH 值上升至约 8 而增加，随后在 pH 值约 9 时下降，这可能是由于电渗力开始对抗电泳力。还测量了几种电解质的 1/f 噪声，发现 LiCl 的性能优于 NaCl、KCl、RbCl 和 CsCl。发现 1/f 噪声随着电解质浓度和孔径的增加而增加。总而言之，这项工作的结果表明，pH 值大约为 7-8 范围是 CT-CDB 纳米孔 DNA 传感的最佳范围。
Recently, we developed a fabrication method—chemically-tuned controlled dielectric breakdown (CT-CDB)—that produces nanopores (through thin silicon nitride membranes) surpassing legacy drawbacks associated with solid-state nanopores (SSNs). However, the noise characteristics of CT-CDB nanopores are largely unexplored. In this work, we investigated the 1/f noise of CT-CDB nanopores of varying solution pH, electrolyte type, electrolyte concentration, applied voltage, and pore diameter. Our findings indicate that the bulk Hooge parameter (αs) is about an order of magnitude greater than SSNs fabricated by transmission electron microscopy (TEM) while the surface Hooge parameter (αb) is ~3 order magnitude greater. Theαs of CT-CDB nanopores was ~5 orders of magnitude greater than theirαb, which suggests that the surface contribution plays a dominant role in 1/f noise. Experiments with DNA exhibited increasing capture rates with pH up to pH ~8 followed by a drop at pH ~9 perhaps due to the onset of electroosmotic force acting against the electrophoretic force. The1/f noise was also measured for several electrolytes and LiCl was found to outperform NaCl, KCl, RbCl, and CsCl. The 1/f noise was found to increase with the increasing electrolyte concentration and pore diameter. Taken together, the findings of this work suggest the pH approximate 7–8 range to be optimal for DNA sensing with CT-CDB nanopores.
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影响因子：
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