Informatics and quantitative analysis in biological imaging.

Informatics and quantitative analysis in biological imaging.
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DOI:
10.1126/science.1082602
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发表时间:
2003-04-04
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Sorger PK
Sorger PK
中科院分区:
其他
文献类型:
--
作者:
Swedlow JR;Goldberg I;Brauner E;Sorger PK

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生物成像现在是一种用于探测细胞结构和动力学的定量技术,并且越来越多地用于基于细胞的筛选。然而,假设驱动的数字图像分析所需的生物信息学工具仍然不成熟。我们正在开发开放式显微镜环境(OME),作为光学显微镜图像数据存储和分析的信息学解决方案。OME的目标是自动化图像分析,建模和大型图像集的挖掘,并指定了一个灵活的数据模型,关系数据库和XML编码的文件标准,可用于任何潜在的软件工具。通过这种设计,OME为生物图像信息学迈出了第一步。
Biological imaging is now a quantitative technique for probing cellular structure and dynamics, and increasingly for cell-based screens. However, the bioinformatics tools required for hypothesis-driven analysis of digital images are still immature. We are developing the Open Microscopy Environment (OME) as an informatics solution for the storage and analysis of optical microscope image data. OME aims to automate image analysis, modeling and mining of large sets of images and specifies a flexible data model, a relational database, and an XML-encoded file standard usable by potentially any software tool. With this design, OME provides a first step toward biological image informatics.
DOI: 10.1016/s0962-8924(00)01880-8
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