Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study.
Serolological Profile Among HBsAg-Positive Infections in Southeast China: A Community-Based Study.
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DOI：
10.5812/hepatmon.7604
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发表时间：
2013-01
影响因子：
0.6
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Chen P;Yu C;Wu W;Wang J;Ruan B;Ren J;Yang S;Xu K;Yu L;Li L
B型肝炎病毒（HBV）感染一直是一个重要的公共卫生问题。在中国建立一个大规模的、以社区为基础的HBV感染概况对预防该疾病至关重要。本研究旨在调查社区HBV感染者的年龄分布、B e抗原（HBeAg）阳性率及其相关危险因素、血清学标志物之间的关系。在两个县的12个社区进行了一项以社区为基础的横断面调查，没有年龄限制。研究人群采用随机多阶段整群抽样。收集了8439例乙肝表面抗原（HBsAg）阳性者的血清学样本和人口统计学信息。年龄< 20岁的人中HBsAg阳性感染者的构成比最低（0.4%），40-49岁的人中最高（33.2%）。感染者HBeAg阳性率为18.5%，且随年龄增长而下降。男性HBeAg阳性率（21.9%）明显高于女性（14.7%），沿海地区（22.9%）明显高于平原地区（12.9%）。在1561例HBeAg阳性者中，HBV DNA阳性率为91.0%。但在6878例HBeAg阴性者中，仅45.4%为HBV DNA阳性，且不同HBV DNA表达水平的HBeAg阳性率有显著性差异。与ALT正常者相比，ALT升高者可检测到HBV DNA水平的比例显著较高，无论HBeAg阳性与否。HBV感染率在> 20岁年龄组仍较高。HBeAg阳性率与年龄、地域、性别有关。HBeAg和血清ALT水平是评价我国基层医院HBV感染性的有效方法。
Hepatitis B virus (HBV) infection has remained a significant public health problem. Generating a large-scale, community-based profile of HBV infection in China is essential to prevention of the disease. The current study was designed to investigate HBV-infected individuals at the community level and determine the age distribution, hepatitis B e antigen (HBeAg) positivity and its related risk factors, relationship among serological markers. A cross-sectional, community-based survey was carried out without age restriction, in 12 communities of two counties. The study population was selected by random multistage cluster sampling. Serological samples and demographic information were collected from 8439 HB surface antigen (HBsAg)-positive individuals. The constituent ratio of individuals with HBsAg-positive infections was lowest among persons aged < 20 years (0.4%) and the highest among persons aged 40-49 years (33.2%). The HBeAg-positive rate among infected individuals was 18.5%, and the constituent ratio decreased with increasing of age. The HBeAg-positive rate in males (21.9%) was significantly higher than in females (14.7%), and was higher among coastland inhabitants (22.9%) than among plains inhabitants (12.9%). Among the 1561 HBeAg-positive individuals, 91.0% were HBV DNA-positive. However, of the 6878 HBeAg-negative individuals, only 45.4% were HBV DNA-positive, and the HBeAg-positive rate was significantly different at different levels of HBV DNA expression. The proportion of detectable HBV DNA levels was significantly higher in individuals with elevated ALT, compared to those with normal ALT, regardless of HBeAg-positivity. The HBV prevalence remained high in the > 20 age group. The positivity of HBeAg was related to age, region, and sex. Testing HBeAg and serum ALT levels were effective ways to assess HBV infectiousness in community-level hospitals in China.
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DOI：
10.1046/j.1440-1746.2003.02976.x
发表时间：
2003-03-01
影响因子：
4.1
作者：
Liaw, YF
通讯作者：
Liaw, YF
DOI：
10.1097/meg.0b013e328347322b
发表时间：
2011-08-01
影响因子：
2.1
作者：
Luo, Zhuanbo;Xie, Yirui;Ruan, Bing
通讯作者：
Ruan, Bing
影响因子：
6.6
作者：
Tsai, Naoky C. S.;Holck, Peter S.;Ricalde, Aldrich A.
通讯作者：
Ricalde, Aldrich A.
DOI：
10.1016/s0928-4346(96)82012-3
发表时间：
1996-05-01
期刊：
INTERNATIONAL HEPATOLOGY COMMUNICATIONS
影响因子：
--
作者：
Xia, GL;Liu, CB;Qi, XQ
通讯作者：
Qi, XQ
影响因子：
13.5
作者：
Chan, HLY;Leung, NWY;Lok, ASF
通讯作者：
Lok, ASF