Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders.
Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders.
复制标题
可卡因使用障碍中增强的提示反应性和额叶功能连通性。
DOI：
10.1016/j.drugalcdep.2011.01.009
复制
发表时间：
2011-05-01
影响因子：
4.2
通讯作者：
Mayer, Andrew R.
中科院分区：
文献类型：
--
作者：
Wilcox, Claire E.;Teshiba, Terri M.;Merideth, Flannery;Ling, Josef;Mayer, Andrew R.
长期使用可卡因与对药物刺激的线索反应增强有关。然而，它也可能改变涉及处理药物刺激的区域的功能连接（fcMRI）。我们的目的是评估涉及主观渴望的神经区域，以及慢性可卡因使用者如何改变fcMRI。14名确诊为可卡因滥用或依赖（CCA）的患者和16名性别、年龄和教育程度相匹配的健康对照（HC）在接受功能磁共振成像时完成了提示反应性任务和静息状态扫描。与HC相比，CCA在可卡因提示下显示左背外侧前额叶和双侧枕叶皮层的激活增加，而对食欲控制刺激没有反应。此外，在层次回归分析中，CCA还显示了相对于食欲刺激，眶额叶皮层（OFC）对可卡因线索的激活增加。主观渴望与内侧扣带后回（PCC）活动之间也存在负相关。线索处理种子区（OFC和腹侧纹状体）与CCA的静息状态相关（正）增加，而线索处理区与PCC/楔前叶之间呈负相关。这些功能磁共振成像的改变可能部分解释了CCA中药物线索显著性增加的神经基础。
Chronic cocaine use is associated with enhanced cue reactivity to drug stimuli. However, it may also alter functional connectivity (fcMRI) in regions involved in processing drug stimuli. Our aims were to evaluate the neural regions involved in subjective craving and how fcMRI may be altered in chronic cocaine users. Fourteen patients with a confirmed diagnosis of cocaine abuse or dependence (CCA) and 16 gender, age, and education-matched healthy controls (HC) completed a cue reactivity task and a resting state scan while undergoing functional magnetic resonance imaging. CCA showed increased activation compared to HC in left dorsolateral prefrontal and bilateral occipital cortex in response to cocaine cues but not to appetitive control stimuli. Moreover, CCA also showed increased activation within the orbital frontal cortex (OFC) for cocaine cues relative to the appetitive stimuli during a hierarchical regression analysis. A negative association between subjective craving and activity in medial posterior cingulate gyrus (PCC) was also observed for CCA. CCA exhibited increased resting state correlation (positive) between cue-processing seed regions (OFC and ventral striatum), and negative connectivity between cue-processing regions and PCC/precuneus. These alterations in fcMRI may partially explain the neural basis of increased drug cue salience in CCA.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Elliott, R.;Agnew, Z.;Deakin, J. F. W.
通讯作者：
Deakin, J. F. W.
影响因子：
4.8
作者：
Fassbender, Catherine;Foxe, John J.;Garavan, Hugh
通讯作者：
Garavan, Hugh