Gut microbiome and dietary patterns in different Saudi populations and monkeys.
Gut microbiome and dietary patterns in different Saudi populations and monkeys.
复制标题
不同沙特人群和猴子的肠道微生物组和饮食模式。
DOI：
10.1038/srep32191
复制
发表时间：
2016-08-31
影响因子：
4.6
通讯作者：
Raoult D
中科院分区：
文献类型：
--
作者：
Angelakis E;Yasir M;Bachar D;Azhar EI;Lagier JC;Bibi F;Jiman-Fatani AA;Alawi M;Bakarman MA;Robert C;Raoult D
宿主遗传学、环境、生活方式和宿主之间的接近程度强烈影响肠道微生物组的组成。为了研究饮食变量与肠道微生物群的关联，我们使用 16S rDNA 测序来测试贝都因人和沙特城市人的粪便微生物组，并将其与与贝都因人密切接触并吃他们的剩菜的狒狒的肠道微生物组进行比较。我们还分析了贝都因人常用的发酵乳制品，以研究它们对该人群肠道微生物组的影响。我们发现，西方城市沙特人的肠道微生物组的丰富度和生物多样性明显低于传统的贝都因人。与城市沙特人相比，狒狒的肠道微生物群与贝都因人更相似，这可能是由于狒狒和贝都因人的饮食重叠所致。此外，我们发现在成分上与人类和狒狒中发现的簇相似，其特征是不动杆菌、图里奇杆菌和柯林斯菌的差异。与城市沙特人相比，发酵食品中贝都因人肠道微生物组常见的细菌属明显更多。这些结果支持饮食习惯影响肠道微生物组组成的假设。
Host genetics, environment, lifestyle and proximity between hosts strongly influence the composition of the gut microbiome. To investigate the association of dietary variables with the gut microbiota, we used 16S rDNA sequencing to test the fecal microbiome of Bedouins and urban Saudis and we compared it to the gut microbiome of baboons living in close contact with Bedouins and eating their leftovers. We also analyzed fermented dairy products commonly consumed by Bedouins in order to investigate their impact on the gut microbiome of this population. We found that the gut microbiomes of westernized urban Saudis had significantly lower richness and biodiversity than the traditional Bedouin population. The gut microbiomes of baboons were more similar to that of Bedouins compared to urban Saudis, probably due the dietary overlap between baboons and Bedouins. Moreover, we found clusters that were compositionally similar to clusters identified in humans and baboons, characterized by differences in Acinetobacter, Turicibacter and Collinsella. The fermented food presented significantly more bacteria genera common to the gut microbiome of Bedouins compared to urban Saudis. These results support the hypothesis that dietary habits influence the composition of the gut microbiome.
登录
查看更多内容
影响因子：
7
作者：
Moeller AH;Peeters M;Ndjango JB;Li Y;Hahn BH;Ochman H
通讯作者：
Ochman H
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
4.4
作者：
Schloss, Patrick D.;Westcott, Sarah L.;Weber, Carolyn F.
通讯作者：
Weber, Carolyn F.
影响因子：
7
作者：
Lozupone CA;Stombaugh J;Gonzalez A;Ackermann G;Wendel D;Vázquez-Baeza Y;Jansson JK;Gordon JI;Knight R
通讯作者：
Knight R
EMBL核苷酸序列数据库：2005年的发展。
影响因子：
14.9
作者：
Cochrane, Guy;Aldebert, Philippe;Althorpe, Nicola;Andersson, Mikael;Baker, Wendy;Baldwin, Alastair;Bates, Kirsty;Bhattacharyya, Sumit;Browne, Paul;van den Broek, Alexandra;Castro, Matias;Duggan, Karyn;Eberhardt, Ruth;Faruque, Nadeem;Gamble, John;Kanz, Carola;Kulikova, Tamara;Lee, Charles;Leinonen, Rasko;Lin, Quan;Lombard, Vincent;Lopez, Rodrigo;McHale, Michelle;McWilliam, Hamish;Mukherjee, Gaurab;Nardone, Francesco;Pastor, Maria Pilar Garcia;Sobhany, Siamak;Stoehr, Peter;Tzouvara, Katerina;Vaughan, Robert;Wu, Dan;Zhu, Weimin;Apweiler, Rolf
通讯作者：
Apweiler, Rolf