An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark.
An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark.
复制标题
对丹麦猪呼吸道疾病复合物相关的病理和病原体的研究。
DOI：
10.1016/j.jcpa.2010.01.012
复制
发表时间：
2010-08
影响因子：
0.8
通讯作者：
Nielsen OL
中科院分区：
文献类型：
--
作者：
Hansen MS;Pors SE;Jensen HE;Bille-Hansen V;Bisgaard M;Flachs EM;Nielsen OL
呼吸道感染是生长猪最重要的疾病之一。为了阐明丹麦猪呼吸道疾病综合征 (PRDC) 的多因素病因学，从屠宰场收集了 148 头患有颅腹支气管肺炎的育肥猪（病例组）和 60 头无肺部病变的猪（对照组）的肺部。鉴定出与 PRDC 相关的病原体及其相互作用，并将其与组织病理学诊断联系起来。对肺部样本进行细菌培养，并通过多重聚合酶链反应检测猪流感病毒（A型）、猪繁殖与呼吸综合征病毒（欧洲型和美国型）、猪圆环病毒2型（PCV2）、猪呼吸道冠状病毒、猪巨细胞病毒、猪肺炎支原体和猪肺炎支原体的存在。 猪鼻支原体。所有病例均患有符合 PRDC 的颅腹小叶支气管肺炎。存在广泛的镜下病变，病例特征为急性（n = 10）、亚急性（n = 24）或慢性（n = 114）支气管肺炎。五种细菌、五种病毒和两种支原体。在不同的组合中被检测到。 PCV2、猪肺炎支原体、猪鼻支原体和多杀性巴氏杆菌在受 PRDC 感染的猪中最常见，且与对照组相比，这些动物中病原体的多样性和数量更高。在病原体和组织学病变或组织病理学诊断之间没有发现明确的关联。在丹麦育肥猪中，PRDC 比地方性肺炎更常见，并且具有复杂多样的组织病理学。
Respiratory infections are among the most important diseases of growing pigs. In order to elucidate the multifactorial aetiology of porcine respiratory disease complex (PRDC) in Denmark, lungs from 148 finishing pigs with cranioventral bronchopneumonia (case group) and 60 pigs without lung lesions (control group) were collected from abattoirs. The pathogens involved in PRDC and their interactions were identified and linked to the histopathological diagnosis. The lung samples were cultured for bacteria and tested by multiplex polymerase chain reaction for presence of swine influenza virus (type A), porcine reproductive and respiratory syndrome virus (both European and US type), porcine circovirus type 2 (PCV2), porcine respiratory coronavirus, porcine cytomegalovirus, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. All cases had cranioventral lobular bronchopneumonia consistent with PRDC. There was a broad range of microscopical lesions and the cases were characterized as acute (n = 10), subacute (n = 24) or chronic (n = 114) bronchopneumonia. Five bacterial species, five viruses and two Mycoplasma spp. were detected in different combinations. PCV2, M. hyopneumoniae, M. hyorhinis and Pasteurella multocida were detected most frequently among the PRDC affected swine and the diversity and number of pathogens were higher in these animals compared with controls. No clear-cut associations were detected between pathogens and histological lesions or histopathological diagnoses. PRDC occurs more frequently than enzootic pneumonia among Danish finishing pigs and has complex and varied histopathology.
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影响因子：
2.2
作者：
Palzer, A.;Ritzmann, M.;Heinritzi, K.
通讯作者：
Heinritzi, K.
DOI：
10.2376/0005-9366-120-483
发表时间：
2007-11-01
影响因子：
0.4
作者：
Palzer, Andreas;Ritzmann, Mathias;Heinritzi, Karl
通讯作者：
Heinritzi, Karl
影响因子：
5.5
作者：
Fachinger, Vicky;Bischoff, Ralf;Elbers, Knut
通讯作者：
Elbers, Knut
影响因子：
0.8
作者：
Kawashima, K;Yamada, S;Narita, M
通讯作者：
Narita, M
影响因子：
2.8
作者：
Liljegren, CH;Aalbæk, B;Jensen, HE
通讯作者：
Jensen, HE