Dental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort study.
Dental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort study.
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幼儿的龋齿及其与口腔微生物群和艾滋病毒的关系--尼日利亚(Domhain)：一项队列研究。
DOI：
10.1186/s12903-021-01944-y
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发表时间：
2021-12-04
期刊：
影响因子：
2.9
通讯作者：
Richards VP
中科院分区：
文献类型：
--
作者：
Coker MO;Akhigbe P;Osagie E;Idemudia NL;Igedegbe O;Chukwumah N;Adebiyi R;Mann AE;O'Connell LM;Obuekwe O;Omoigberale A;Charurat ME;Richards VP
本研究旨在通过检查斑块微生物组与围产期艾滋病毒感染和暴露之间的关系，更好地了解感染艾滋病毒的尼日利亚学龄儿童龋齿风险增加的机制。我们还试图研究围产期HIV感染和暴露如何影响牙齿特异性微生物组对龋齿疾病进展的作用。这项研究的参与者是2019年5月至11月期间从尼日利亚贝宁大学教学医院（UBTH）招募的4至11岁儿童。总体而言，568名儿童分为三组：189名HIV感染者（HI），189名HIV暴露但未感染者（HEU）和190名HIV未暴露且未感染者（HUU）作为对照组，访视2和访视3的脱落率分别为2.99%和4.90%。通过标准化问卷调查获得数据。采集血液样本用于HIV、HBV和HCV筛查; CD 4、CD 8和全血细胞计数分析;储存血浆样本用于未来研究;在不同研究访视时，从受试者中无菌采集口腔样本，包括唾液、口腔拭子、口咽拭子、舌拭子、牙菌斑。该研究的结果将提供有关艾滋病毒暴露、感染和治疗如何影响儿童口腔微生物组和龋齿易感性的关键信息。通过确定对牙科微生物群落分类结构和基因表达的影响，我们将阐明可能导致龋齿发生的机制。作为未来的计划，呼吸道感染，免疫和炎症标志物与龋齿在围产期艾滋病毒感染和暴露之间的关系将进行调查。在线版本包含补充材料，可在10.1186/s12903-021-01944-y获得。
This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinatal HIV infection and exposure impact tooth-specific microbiomes' role on caries disease progression. The participants in this study were children aged 4 to 11 years recruited from the University of Benin Teaching Hospital (UBTH), Nigeria, between May to November 2019. Overall, 568 children were enrolled in three groups: 189 HIV-infected (HI), 189 HIV-exposed but uninfected (HEU) and 190 HIV-unexposed and uninfected (HUU) as controls at visit 1 with a 2.99% and 4.90% attrition rate at visit 2 and visit 3 respectively. Data were obtained with standardized questionnaires. Blood samples were collected for HIV, HBV and HCV screening; CD4, CD8 and full blood count analysis; and plasma samples stored for future investigations; oral samples including saliva, buccal swabs, oropharyngeal swab, tongue swab, dental plaque were collected aseptically from participants at different study visits. Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated. The online version contains supplementary material available at 10.1186/s12903-021-01944-y.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1007/s12070-011-0370-z
发表时间：
2014-01-01
影响因子：
0.6
作者：
Hegde, Mahesh Chandra;Kumar, Abhijit;Sreedharan, Suja
通讯作者：
Sreedharan, Suja
DOI：
10.14219/jada.archive.1964.0034
发表时间：
1964-01-01
影响因子：
3.9
作者：
GREENE, JC;VERMILLION, JR
通讯作者：
VERMILLION, JR
影响因子：
4.6
作者：
Griffen, Ann L.;Thompson, Zachary A.;Fidel, Paul L., Jr.
通讯作者：
Fidel, Paul L., Jr.
影响因子：
3.8
作者：
Brennan, Alana T.;Bonawitz, Rachael;Fox, Matthew P.
通讯作者：
Fox, Matthew P.