Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature.
Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature.
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澳大利亚东部（2002-2005）和文献综述的22例犬神经血管中病。
DOI：
10.1186/1756-3305-5-70
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发表时间：
2012-04-05
影响因子：
3.2
通讯作者：
Malik R
中科院分区：
文献类型：
--
作者：
Lunn JA;Lee R;Smaller J;MacKay BM;King T;Hunt GB;Martin P;Krockenberger MB;Spielman D;Malik R
病例犬神经性血管线虫病（NA）与脑脊液（CSF）评估在同行评议的文献被制成表格。所有病例均来自澳大利亚。对59只犬的回顾性队列与22例新病例进行对比，这些病例通过ELISA或Western blot检测脑脊液中嗜酸性粒细胞增多症和抗广东血管线虫免疫球蛋白（IgG）的存在来诊断NA。两组研究对象均来自昆士兰东南部和悉尼。该回顾性队列主要包括后肢无力伴感觉过度，后肢上运动神经元（UMN）和下运动神经元（LMN）混合体征和尿失禁的幼崽。体征归因于幼虫通过周围神经，神经根，脊髓和大脑迁移，与上升嗜酸性粒细胞性脑脊髓炎相关。当代队列包括幼犬，年轻成年犬和成年犬，具有更广泛的体征，包括(i)麻痹/本体感受性共济失调（ii）腰椎和尾基感觉亢进，（iii）多灶性中枢神经系统功能障碍，或（iv）局灶性疾病伴颈部疼痛，颅神经病变和精神状态改变。病例全年可见，大多数发生在4月至7月（包括4月和7月）。大品种占优势。通常情况下，同窝的伴侣或同一狗窝的多只动物会同时或依次受到影响。推定诊断是基于一致的迹象，接近大鼠，摄入/咀嚼鼻涕虫或蜗牛和嗜酸性多细胞症。通过显示抗a来诊断NA。CSF中广东人IgG的表达。检测从。血清中的广东人IgG没有帮助，因为许多正常的狗（20/21磅的狗；8/22的医院人口）都有这种抗体，通常滴度很高。在回顾性队列中，大多数NA病例（19/22）和许多幼崽（16/38）使用高剂量强的松龙和阿片类药物成功治疗。治疗通常包括抗生素给予的情况下，原生动物脑脊髓炎或易位性细菌性脑膜炎。支持措施包括膀胱护理和物理治疗。有几只狗留下了永久性的神经缺陷。狗是NA重要的哨兵物种。在研究期间，与受影响的狗在同一地区报告了人类病例和许多茶色蛙嘴病例。本文的在线版本（doi:10.1186/1756-3305-5-70）包含补充材料，可供授权用户使用。
Cases of canine neural angiostrongylosis (NA) with cerebrospinal fluid (CSF) evaluations in the peer-reviewed literature were tabulated. All cases were from Australia. A retrospective cohort of 59 dogs was contrasted with a series of 22 new cases where NA was diagnosed by the presence of both eosinophilic pleocytosis and anti-Angiostrongylus cantonensis immunloglobulins (IgG) in CSF, determined by ELISA or Western blot. Both cohorts were drawn from south east Queensland and Sydney. The retrospective cohort comprised mostly pups presented for hind limb weakness with hyperaesthesia, a mixture of upper motor neurone (UMN) and lower motor neurone (LMN) signs in the hind limbs and urinary incontinence. Signs were attributed to larval migration through peripheral nerves, nerve roots, spinal cord and brain associated with an ascending eosinophilic meningo-encephomyelitis. The contemporary cohort consisted of a mixture of pups, young adult and mature dogs, with a wider range of signs including (i) paraparesis/proprioceptive ataxia (ii) lumbar and tail base hyperaesthesia, (iii) multi-focal central nervous system dysfunction, or (iv) focal disease with neck pain, cranial neuropathy and altered mentation. Cases were seen throughout the year, most between April and July (inclusive). There was a preponderance of large breeds. Often littermates, or multiple animals from the same kennel, were affected simultaneously or sequentially. A presumptive diagnosis was based on consistent signs, proximity to rats, ingestion/chewing of slugs or snails and eosinophilic pleocytosis. NA was diagnosed by demonstrating anti-A. cantonensis IgG in CSF. Detecting anti-A. cantonensis IgG in serum was unhelpful because many normal dogs (20/21 pound dogs; 8/22 of a hospital population) had such antibodies, often at substantial titres. Most NA cases in the contemporary series (19/22) and many pups (16/38) in the retrospective cohort were managed successfully using high doses of prednisolone and opioids. Treatment often included antibiotics administered in case protozoan encephalomyelitis or translocated bacterial meningitis was present. Supportive measures included bladder care and physiotherapy. Several dogs were left with permanent neural deficits. Dogs are an important sentinel species for NA. Human cases and numerous cases in tawny frogmouths were reported from the same regions as affected dogs over the study period. The online version of this article (doi:10.1186/1756-3305-5-70) contains supplementary material, which is available to authorized users.
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影响因子：
1.1
作者：
Barrett, JL;Carlisle, MS;Prociv, P
通讯作者：
Prociv, P
DOI：
10.1016/0035-9203(86)90324-x
发表时间：
1986-01-01
影响因子：
2.2
作者：
CHEN, SN
通讯作者：
CHEN, SN
影响因子：
4
作者：
BHAIBULAYA, M
通讯作者：
BHAIBULAYA, M
影响因子：
2
作者：
Al-Sabi, Mohammad N. S.;Deplazes, Peter;Kapel, Christian M. O.
通讯作者：
Kapel, Christian M. O.
影响因子：
1.1
作者：
Carlisle, MS;Prociv, P;Mudie, A
通讯作者：
Mudie, A