The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia.

The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia.
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DOI:
10.1016/j.cimid.2012.01.003
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发表时间:
2012-05
期刊:
Comparative immunology, microbiology and infectious diseases
影响因子:
--
通讯作者:
Young DB
Young DB
中科院分区:
其他
文献类型:
--
作者:
Vordermeier M;Ameni G;Berg S;Bishop R;Robertson BD;Aseffa A;Hewinson RG;Young DB

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Bovine tuberculosis in domestic livestock such as cattle is an economically important disease with zoonotic potential, particularly in countries with emerging economies. We discuss the findings of recent epidemiological and immunological studies conducted in Ethiopia on host susceptibility differences between native zebu and the exotic Holstein–Friesian cattle that are increasingly part of the Ethiopian National herd, due to the drive to increase milk yields. These findings support the hypothesis that native Zebu cattle are more resistant to bovine tuberculosis. We also summarise the results of experimental infections that support the epidemiological data, and of laboratory experiments that suggest a role for the innate immune response, and in particular interleukin-6, in the outcome of bovine tuberculosis infection.
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