LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions.
LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions.
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DOI：
10.1016/j.celrep.2021.109714
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发表时间：
2021-09-14
期刊：
影响因子：
8.8
通讯作者：
Ji, Daoyun
中科院分区：
文献类型：
--
作者：
Domenico, Carli;Haggerty, Daniel;Mou, Xiang;Ji, Daoyun
麦角酸二乙胺(LSD)会产生幻觉，这种幻觉是与外部环境脱钩的感觉。LSD是如何改变体内神经元活动的，这是异常感知的基础，目前尚不清楚。在这里，我们展示了当大鼠沿着熟悉的轨迹跑步时，LSD作用下的海马区细胞减少了它们的放电率，它们的方向性，以及它们与视觉皮质神经元的相互作用。然而，海马神经元和视皮层神经元在头部抽动时都会暂时增加放电频率，这是啮齿动物类幻觉状态的行为特征。当大鼠在跑道上不动时，LSD在类似于从清醒到睡眠的转换状态下增强皮质放电的同步性，在此期间，海马区-皮质相互作用保持抑制，而海马区清醒的重新激活保持不变。我们的结果表明，LSD抑制了活跃行为和静止期间的海马-皮质相互作用，导致海马内部表征退化并与外部感觉输入隔离。这些影响可能会导致LSD产生的异常感知。多梅尼科等人。研究麦角酸二乙胺(LSD)对海马区细胞和视皮层神经元的影响。在主动导航过程中，LSD降低了海马区-视觉皮层的相关性和海马区的空间表征精度。在不动的行为中，LSD促进孤立的海马区重新激活，并产生类似于从清醒到睡眠的转换的皮质状态。
Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. How LSD alters neuronal activities in vivo that underlie abnormal perceptions is unknown. Here, we show that when rats run along a familiar track, hippocampal place cells under LSD reduce their firing rates, their directionality, and their interaction with visual cortical neurons. However, both hippocampal and visual cortical neurons temporarily increase firing rates during head-twitching, a behavioral signature of a hallucination-like state in rodents. When rats are immobile on the track, LSD enhances cortical firing synchrony in a state similar to the wakefulness-to-sleep transition, during which the hippocampal-cortical interaction remains dampened while hippocampal awake reactivation is maintained. Our results suggest that LSD suppresses hippocampal-cortical interactions during active behavior and during immobility, leading to internal hippocampal representations that are degraded and isolated from external sensory input. These effects may contribute to LSD-produced abnormal perceptions. Domenico et al. investigate how lysergic acid diethylamide (LSD) affects hippocampal place cells and visual cortical neurons. During active navigation, LSD reduces hippocampal-visual cortical correlation and hippocampal spatial representation precision. During immobile behavior, LSD promotes isolated hippocampal reactivation and produces a cortical state similar to wakefulness-to-sleep transition.
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DOI：
10.1038/npp.2017.86
发表时间：
2017-10
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Liechti ME
通讯作者：
Liechti ME
影响因子：
7.7
作者：
Alamia A;Timmermann C;Nutt DJ;VanRullen R;Carhart-Harris RL
通讯作者：
Carhart-Harris RL
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
25
作者：
Karlsson, Mattias P.;Frank, Loren M.
通讯作者：
Frank, Loren M.
影响因子：
3.4
作者：
ADAMS, LM;GEYER, MA
通讯作者：
GEYER, MA