Predicting response to radiotherapy in tumors with PET/CT: when and how?
Predicting response to radiotherapy in tumors with PET/CT: when and how?
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PET/CT预测肿瘤放疗反应：何时及如何预测？
DOI：
10.21037/tcr.2020.03.16
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发表时间：
2020-04
影响因子：
0.9
通讯作者：
Yu Q
中科院分区：
文献类型：
--
作者：
Shen LF;Zhou SH;Yu Q
放射治疗是肿瘤治疗的主要手段之一，随着放射治疗技术的不断改进，寻找有效可行的肿瘤放射敏感性预测方法越来越受到人们的关注。基于放射治疗后肿瘤代谢、微血管密度、缺氧微环境、细胞因子等一系列变化，研究了多种放射敏感性检测方法。在检测方法中，正电子发射断层扫描-计算机断层扫描（PET/CT）是一种可行的工具，用于癌症的明确放疗后的反应评估，具有高阴性预测值。PET/CT的预后或预测价值目前正在广泛研究。然而，PET/CT放射敏感性预测的最佳探头，最有用的PET/CT参数的选择及其最佳截断值，如总病变糖酵解（TLG）、代谢肿瘤体积（MTV）和标准化摄取值（SUV），以及PET/CT预治疗的最佳时机，在RT期间或之后，还有许多问题没有解决。放射治疗作用的模式和分次调度可能使适当的选择复杂化。在这项研究中，我们将讨论各种方法来评估放射敏感性，并将重点放在选择最佳的探头，时间，截止值和参数的PET/CT的放射治疗反应进行评估。
Radiotherapy is one of the main methods for tumor treatment, with the improved radiotherapy delivery technique to combat cancer, there is a growing interest for finding effective and feasible ways to predict tumor radiosensitivity. Based on a series of changes in metabolism, microvessel density, hypoxic microenvironment, and cytokines of tumors after radiotherapy, a variety of radiosensitivity detection methods have been studied. Among the detection methods, positron emission tomography-computed tomography (PET/CT) is a feasible tool for response evaluation following definitive radiotherapy for cancers with a high negative predictive value. The prognostic or predictive value of PET/CT is currently being studied widely. However, there are many unresolved issues, such as the optimal probe of PET/CT for radiosensitivity prediction, the selection of the most useful PET/CT parameters and their optimal cut-offs such as total lesion glycolysis (TLG), metabolic tumor volume (MTV) and standardized uptake value (SUV), and the optimal timing of PET/CT pre-treatment, during or following RT. Different radiosensitivity of tumors, modes of radiotherapy action and fraction scheduling may complicate the appropriate choice. In this study, we will discuss the diverse methods for evaluating radiosensitivity, and will also focus on the selection of the optimal probe, timing, cut-offs and parameters of PET/CT for evaluating the radiotherapy response.
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影响因子：
3.4
作者：
Chua, M. L. K.;Rothkamm, K.
通讯作者：
Rothkamm, K.
影响因子：
2.6
作者：
Chen, Shang-Wen;Hsieh, Te-Chun;Kao, Chia-Hung
通讯作者：
Kao, Chia-Hung
DOI：
10.1186/s13014-018-0984-3
发表时间：
2018-03-07
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Melsens E;De Vlieghere E;Descamps B;Vanhove C;Kersemans K;De Vos F;Goethals I;Brans B;De Wever O;Ceelen W;Pattyn P
通讯作者：
Pattyn P
DOI：
10.1016/j.mric.2015.08.003
发表时间：
2016-02-01
影响因子：
1.6
作者：
Garcia-Figueiras, Roberto;Padhani, Anwar R.;Baleato-Gonzalez, Sandra
通讯作者：
Baleato-Gonzalez, Sandra
DOI：
10.1007/s00259-015-3051-4
发表时间：
2015-08-01
影响因子：
9.1
作者：
Kim, Ji Won;Oh, Jungsu S.;Kim, Sang Yoon
通讯作者：
Kim, Sang Yoon