Possible influence of mammographic density on local and locoregional recurrence of breast cancer.
Possible influence of mammographic density on local and locoregional recurrence of breast cancer.
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DOI：
10.1186/bcr3450
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hall P
中科院分区：
文献类型：
--
作者：
Eriksson L;Czene K;Rosenberg L;Humphreys K;Hall P
关于乳房X光检查密度是否会导致更具侵袭性的癌症，目前还存在争议。因此，我们的目的是研究钼靶密度对预后的影响。这是一项基于人群的病例对照研究中的仅病例研究。病例均为瑞典绝经后女性，1993-1995年确诊为偶发乳腺癌，年龄50-74岁。包括诊断前/诊断乳房X光检查的妇女(n=1774)。使用计算机辅助阈值技术评估未受影响的乳房的钼靶摄影密度。用COX比例风险模型研究了外科手术(保乳手术与乳房切除术)分层前后的复发率和存活率。即使对已建立的预测因素进行调整后，百分比密度(PD)也与局部和局部复发有关；对于PD≥为25%的PD<；女性，局部复发的危险比(HR)为1.92，p=0.039，局部区域复发的危险比(HR)为1.67，p=0.033。对手术程序的分层显示，这种关联也存在于乳房切除的女性中。帕金森病与远处复发和生存无关。高密度钼靶摄影是局部和局部复发的独立危险因素，但与远处转移和生存无关。在接受乳房切除术的女性中，也存在与局部和局部复发的关系，这表明它们不仅仅是因为接受保乳手术的女性的密度掩盖了残留疾病。相反，这似乎是一种真正的联系。因此，乳房X光摄影密度可能会影响未来的辅助治疗决定。
It is debated whether mammographic density gives rise to more aggressive cancers. We therefore aimed to study the influence of mammographic density on prognosis. This is a case-only study within a population-based case-control study. Cases were all postmenopausal women in Sweden with incident breast cancer, diagnosed 1993-1995, and aged 50-74 years. Women with pre-diagnostic/diagnostic mammograms were included (n = 1774). Mammographic density of the unaffected breast was assessed using a computer-assisted thresholding technique. The Cox proportional hazards model was used to study recurrence and survival with and without stratification on surgical procedure (breast-conserving surgery vs. mastectomy). Percentage density (PD) was associated with both local and locoregional recurrence even after adjustment for established prognosticators; hazards ratio (HR) 1.92, p = 0.039, for local recurrence and HR 1.67, p = 0.033, for locoregional recurrence for women with PD≥25% compared to PD<25%. Stratification on surgical procedure showed that the associations were also present in mastectomized women. PD was neither associated with distant recurrence nor survival. High mammographic density is an independent risk factor of local and locoregional recurrence but is neither associated with distant metastasis nor survival. The relationships with local and locoregional recurrences were also present in women treated with mastectomy, indicating that they are not merely explained by density masking residual disease in women treated with breast-conserving surgery. Rather there appears to be a true association. Thus, mammographic density should possibly influence adjuvant therapy decisions in the future.
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影响因子：
6.4
作者：
Heusinger, Katharina;Jud, Sebastian M.;Fasching, Peter A.
通讯作者：
Fasching, Peter A.
影响因子：
45.3
作者：
Goldhirsch, A;Glick, JH;Senn, HJ
通讯作者：
Senn, HJ
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
6.7
作者：
Colacurci, N;Fornaro, F;del Vecchio, W
通讯作者：
del Vecchio, W
影响因子：
3.8
作者：
Li, T;Sun, LM;Boyd, N
通讯作者：
Boyd, N