A graded tractographic parcellation of the temporal lobe.
A graded tractographic parcellation of the temporal lobe.
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DOI：
10.1016/j.neuroimage.2017.04.016
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发表时间：
2017-07-15
期刊：
影响因子：
5.7
通讯作者：
Cloutman LL
中科院分区：
文献类型：
--
作者：
Bajada CJ;Jackson RL;Haroon HA;Azadbakht H;Parker GJM;Lambon Ralph MA;Cloutman LL
通过损伤研究以及认知神经影像学研究，颞叶与多个认知领域有关。最近，人们对这些功能背后的结构和连接架构越来越感兴趣。然而，目前还没有一个全面的探索模式的连接，出现在整个颞叶。本文使用数据驱动的频谱重排方法，以了解颞叶内结构连接的一般轴。这项研究得出了两个重要的发现。首先，颞叶的总体模式的连接组织沿着两个关键的结构轴：内侧到外侧和前腹到后背，反映在功能性文献的结果。其次，颞叶的连接组织是分级的和过渡的;这让人想起19世纪世纪神经解剖学家的原始工作，他们假设存在一些区域，这些区域以分级的方式相互过渡。虽然存在具有独特连通性的区域，但这些区域之间的边界并不总是清晰的。相反，存在反映共享连通性的影响和重叠的分级连通性区域。一个分级的包裹确定了颞叶连接的变化颞叶的连接组织是分级的和过渡的两个组织轴被发现：内侧-外侧和前腹-后背虽然存在不同的连接区域，但它们的边界并不总是清晰的，存在分级连接区域，反映了共享连接的影响。
The temporal lobe has been implicated in multiple cognitive domains through lesion studies as well as cognitive neuroimaging research. There has been a recent increased interest in the structural and connective architecture that underlies these functions. However there has not yet been a comprehensive exploration of the patterns of connectivity that appear across the temporal lobe. This article uses a data driven, spectral reordering approach in order to understand the general axes of structural connectivity within the temporal lobe. Two important findings emerge from the study. Firstly, the temporal lobe's overarching patterns of connectivity are organised along two key structural axes: medial to lateral and anteroventral to posterodorsal, mirroring findings in the functional literature. Secondly, the connective organisation of the temporal lobe is graded and transitional; this is reminiscent of the original work of 19th Century neuroanatomists, who posited the existence of some regions which transitioned between one another in a graded fashion. While regions with unique connectivity exist, the boundaries between these are not always sharp. Instead there are zones of graded connectivity reflecting the influence and overlap of shared connectivity. A graded parcellation identified changes in connectivity across the temporal lobe Connective organisation of the temporal lobe was graded and transitional Two axes of organisation were found: medial-lateral and anterovental-posterodorsal While regions of distinct connectivity exist, their boundaries are not always sharp Zones of graded connectivity exist reflecting influence of shared connectivity
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