Higher Viral Stability and Ethanol Resistance of Avian Influenza A(H5N1) Virus on Human Skin.
Higher Viral Stability and Ethanol Resistance of Avian Influenza A(H5N1) Virus on Human Skin.
复制标题
DOI：
10.3201/eid2803.211752
复制
发表时间：
2022-03
影响因子：
11.8
通讯作者：
Ikegaya H
中科院分区：
文献类型：
--
作者：
Bandou R;Hirose R;Nakaya T;Miyazaki H;Watanabe N;Yoshida T;Daidoji T;Itoh Y;Ikegaya H
评估高致病性禽流感病毒在人体皮肤上的稳定性和测量消毒剂的有效性对预防接触性疾病传播至关重要。我们利用尸体解剖皮肤样本构建了一个评估模型，并评估了影响各种亚型的稳定性和消毒效果的因素。甲型H5N1禽流感病毒在塑料表面的存活时间≈26小时，在皮肤表面的存活时间≈4.5小时，比其他亚型的存活时间长2.5倍。与其他亚型相比，较低乙醇浓度（32%-36% wt/wt）对H5N1亚型的有效性大大降低。此外，具有H5N1型神经氨酸酶基因的重组病毒在塑料和皮肤表面的存活时间比其他重组病毒长，并且对乙醇具有抗性。我们的结果表明H5N1亚型具有较高的接触传播风险，因为它具有较高的稳定性和乙醇抗性，这可能取决于神经氨酸酶蛋白。
Evaluating the stability of highly pathogenic avian influenza viruses on human skin and measuring the effectiveness of disinfectants are crucial for preventing contact disease transmission. We constructed an evaluation model using autopsy skin samples and evaluated factors that affect the stability and disinfectant effectiveness for various subtypes. The survival time of the avian influenza A(H5N1) virus on plastic surfaces was ≈26 hours and on skin surfaces ≈4.5 hours, >2.5-fold longer than other subtypes. The effectiveness of a relatively low ethanol concentration (32%–36% wt/wt) against the H5N1 subtype was substantially reduced compared with other subtypes. Moreover, recombinant viruses with the neuraminidase gene of H5N1 survived longer on plastic and skin surfaces than other recombinant viruses and were resistant to ethanol. Our results imply that the H5N1 subtype poses a higher contact transmission risk because of its higher stability and ethanol resistance, which might depend on the neuraminidase protein.
登录
查看更多内容
影响因子：
3.7
作者：
Mathur MB;Patel RB;Gould M;Uyeki TM;Bhattacharya J;Xiao Y;Gillaspie Y;Chae C;Khazeni N
通讯作者：
Khazeni N
影响因子：
6.9
作者：
Chan, K-H;Sridhar, S.;Yuen, K-Y
通讯作者：
Yuen, K-Y
影响因子：
1.2
作者：
Hansen, Stephanie;Zimmerman, Peta-Anne;van de Mortel, Thea F
通讯作者：
van de Mortel, Thea F
影响因子：
1.4
作者：
Hauck, R.;Crossley, B.;Gallardo, R. A.
通讯作者：
Gallardo, R. A.
影响因子：
6.9
作者：
Gehrke, C;Steinmann, J;Goroncy-Bermes, P
通讯作者：
Goroncy-Bermes, P