Brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6.
Brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6.
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两岁自闭症儿童大脑对词语的反应可预测六岁时的发育结果。
DOI：
10.1371/journal.pone.0064967
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Dawson G
中科院分区：
文献类型：
--
作者：
Kuhl PK;Coffey-Corina S;Padden D;Munson J;Estes A;Dawson G
自闭症谱系障碍（ASD）是一种影响社会行为和语言习得的发育障碍。ASD在结果上表现出很大的变异性，一些人保持非语言，另一些人表现出平均或高于平均的功能。认知能力有助于自闭症的异质性，并作为后期功能的适度预测因子。我们发现，在2岁（N = 24）时评估的ASD儿童的文字处理的大脑测量（事件相关电位，ERP）是4岁和6岁时接受语言，认知能力和适应行为的广泛而强大的预测因子，无论在干预期间的强化临床治疗形式如何。 这种大脑测量的预测强度随着时间的推移而增加，并且超过了这里用于比较的认知能力测量的预测强度。这些发现具有理论意义，并可能最终导致神经措施，允许早期预测发育结果以及更个性化的临床干预措施，有可能更有效地治疗ASD儿童。
Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD.
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影响因子：
16.2
作者：
Kuhl, Patricia K.
通讯作者：
Kuhl, Patricia K.
影响因子：
2.5
作者：
Akechi, Hironori;Senju, Atsushi;Hasegawa, Toshikazu
通讯作者：
Hasegawa, Toshikazu
影响因子：
11.2
作者：
De Fossé, L;Hodge, SM;Harris, GJ
通讯作者：
Harris, GJ
DOI：
10.1016/j.cub.2011.12.056
发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team
影响因子：
3.7
作者：
Kuhl, Patricia K.
通讯作者：
Kuhl, Patricia K.