Skin stem cells: rising to the surface.
Skin stem cells: rising to the surface.
复制标题
皮肤干细胞：上升到表面。
DOI：
10.1083/jcb.200708185
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发表时间：
2008-01-28
影响因子：
7.8
通讯作者：
Fuchs, Elaine
中科院分区：
文献类型：
--
作者：
Fuchs, Elaine
皮肤表皮及其附属物提供了一个保护屏障，是不可渗透的有害微生物，也防止脱水。为了在面对环境的物理化学创伤的同时执行其功能，这些组织通过稳态经历持续的再生，并且，此外，它们必须准备好进行响应于损伤的伤口修复。皮肤的干细胞是维持组织稳态、再生毛发和修复受伤后表皮的灵丹妙药，它们存在于成年毛囊、皮脂腺和表皮中。干细胞具有自我延续和产生构成一个或多个组织的分化细胞的显著能力。近年来，科学家们已经开始发现皮肤干细胞的特性，并揭开其非凡能力背后的奥秘。在本文中，我概述了皮肤上皮细胞的基本谱系，并回顾了过去五年中出现的有关哺乳动物皮肤上皮干细胞的一些主要发现。
The skin epidermis and its appendages provide a protective barrier that is impermeable to harmful microbes and also prevents dehydration. To perform their functions while being confronted with the physicochemical traumas of the environment, these tissues undergo continual rejuvenation through homeostasis, and, in addition, they must be primed to undergo wound repair in response to injury. The skin's elixir for maintaining tissue homeostasis, regenerating hair, and repairing the epidermis after injury is its stem cells, which reside in the adult hair follicle, sebaceous gland, and epidermis. Stem cells have the remarkable capacity to both self-perpetuate and also give rise to the differentiating cells that constitute one or more tissues. In recent years, scientists have begun to uncover the properties of skin stem cells and unravel the mysteries underlying their remarkable capacity to perform these feats. In this paper, I outline the basic lineages of the skin epithelia and review some of the major findings about mammalian skin epithelial stem cells that have emerged in the past five years.
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影响因子：
6.5
作者：
Estrach, Soline;Cordes, Ralf;Watt, Fiona M.
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.0507250102
发表时间：
2005-10-11
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
COTSARELIS, G;SUN, TT;LAVKER, RM
通讯作者：
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