Novel technologies for the prevention and treatment of dental caries: a patent survey.
Novel technologies for the prevention and treatment of dental caries: a patent survey.
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DOI：
10.1517/13543771003720491
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发表时间：
2010-05
影响因子：
6.6
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Chen F;Wang D
龋齿是最常见的可预防的儿童疾病之一;人们一生都容易患上这种疾病。在美国，90%的晚期青少年和年轻人患有龋齿，而94%的成年人有治疗或未治疗的冠状龋齿证据。龋齿通常不是自限性的，如果没有适当的护理，龋齿会发展到牙齿被破坏。本文简要介绍了龋病的病因学。随后，对有关预防和治疗龋齿的各种新技术的最新发展的专利和文献进行了全面的审查。分析了抗菌斑药物的最新进展，包括化学预防剂、抗菌肽、疫苗、益生菌/替代疗法和糖替代品，以及氟化物和酪蛋白磷酸肽等微生物制剂。新的防龋药物的发现和致龋给药系统的开发将是今后的研究重点。
Dental caries is one of the most common preventable childhood diseases; people are susceptible to this ailment throughout their lifetime. In the United States, 90% of late adolescents and young adults have dental caries, while 94% of all dentate adults had evidence of treated or untreated coronal caries. Dental caries is often not self-limiting and without proper care, caries can progress until the tooth is destroyed. In this paper, the etiology of dental caries was briefly introduced. It was followed by a thorough review of patents and literatures on the recent development of various novel technologies for the prevention and treatment of dental caries. Recent advances in anti-plaque agents, including chemoprophylactic agents, antimicrobial peptides, vaccines, probiotics/replacement therapy and sugar substitutes, and remineralization agents including fluorides and casein phosphopeptides are analyzed. Both the discovery of new anti-caries agents and the development of dentotropic delivery systems will be the future focus of this research field.
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影响因子：
6.7
作者：
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通讯作者：
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DOI：
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