Electrocardiographic and respiratory responses to coal-fired power plant emissions in a rat model of acute myocardial infarction: results from the Toxicological Evaluation of Realistic Emissions of Source Aerosols Study.
Electrocardiographic and respiratory responses to coal-fired power plant emissions in a rat model of acute myocardial infarction: results from the Toxicological Evaluation of Realistic Emissions of Source Aerosols Study.
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DOI：
10.3109/08958378.2010.554461
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发表时间：
2011-08
影响因子：
2.1
通讯作者：
Godleski JJ
中科院分区：
文献类型：
--
作者：
Wellenius GA;Diaz EA;Gupta T;Ruiz PA;Long M;Kang CM;Coull BA;Godleski JJ
燃煤电厂产生的环境颗粒物（PM）可能对心血管有重要影响，但现有的毒理学研究不足以了解这些影响。源气溶胶实际排放的毒理学评价（TERESA）研究旨在评估燃煤电厂产生的一次和二次PM的毒性。作为这项工作的一部分，我们在易感动物中评估了暴露条件下烟囱排放对心脏电生理和呼吸功能的影响，这些暴露条件旨在模拟具有未中和酸度和二次有机气溶胶的老化烟羽（POS暴露情景）。急性心肌梗死大鼠暴露于单个发电厂的烟囱排放（n=15）或过滤空气（n=14） 5小时。通过遥测持续监测呼吸和心电图，并评估心率、心率变异性（HRV）、室性早搏（PVB）频率、心电图间隔时间、呼吸间隔时间和容积。在另一个发电厂进行了类似的实验，但没有成功。POS暴露（细颗粒物质量= 219.1 μg/m3；总硫酸盐= 172.5 μg/m3；酸性硫酸盐= 132.5 μg/m3；有机碳= 50.9 μg/m3）与PVB频率增加、呼吸呼气时间和吸气末暂停时间缩短有关，但与心率、HRV或心电图间期的变化无关。第二个发电厂的结果是无法解释的。根据POS情景模拟，短期暴露于燃煤电厂老化排放物形成的初级和未中和二级颗粒物可能与易感动物室性心律失常风险增加有关。
Ambient particulate matter (PM) derived from coal-fired power plants may have important cardiovascular effects, but existing toxicological studies are inadequate for understanding these effects. The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study aims to evaluate the toxicity of primary and secondary PM derived from coal-fired power plants. As part of this effort, we evaluated in susceptible animals the effect of stack emissions on cardiac electrophysiology and respiratory function under exposure conditions intended to simulate an aged plume with unneutralized acidity and secondary organic aerosols (POS exposure scenario). Rats with acute myocardial infarction were exposed to either stack emissions (n=15) or filtered air (n=14) for 5 hours at a single power plant. Respiration and electrocardiograms were continuously monitored via telemetry and heart rate, heart rate variability (HRV), premature ventricular beat (PVB) frequency, electrocardiographic intervals, and respiratory intervals and volumes were evaluated. Similar experiments at another power plant were attempted but were unsuccessful. POS exposure (fine particle mass = 219.1 μg/m3; total sulfate = 172.5 μg/m3; acidic sulfate = 132.5 μg/m3; organic carbon = 50.9 μg/m3) was associated with increased PVB frequency and decreased respiratory expiratory time and end-inspiratory pause, but not with changes in heart rate, HRV, or electrocardiographic intervals. Results from a second power plant were uninterpretable. Short-term exposure to primary and unneutralized secondary particulate matter formed from aged emissions from a coal-fired power plant, as simulated by the POS scenario, may be associated with increased risk of ventricular arrhythmias in susceptible animals.
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DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
24.3
作者：
Devlin, RB;Ghio, AJ;Cascio, W
通讯作者：
Cascio, W
影响因子：
10.4
作者：
Gurgueira SA;Lawrence J;Coull B;Murthy GG;González-Flecha B
通讯作者：
González-Flecha B
暴露于源气溶胶现实排放的大鼠的心脏和肺氧化应激。
影响因子：
2.1
作者：
Lemos M;Diaz EA;Gupta T;Kang CM;Ruiz P;Coull BA;Godleski JJ;Gonzalez-Flecha B
通讯作者：
Gonzalez-Flecha B
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM