Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment.
Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment.
复制标题
与年龄相关的基础前脑胆碱能和GABA能投射神经元的变化：与空间障碍的关系。
DOI：
10.1016/j.neurobiolaging.2012.06.013
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发表时间：
2013-03
影响因子：
4.2
通讯作者：
Bizon JL
中科院分区：
文献类型：
--
作者：
Bañuelos C;LaSarge CL;McQuail JA;Hartman JJ;Gilbert RJ;Ormerod BK;Bizon JL
来自吻端基底前脑的胆碱能和 GABA 能投射都与海马功能和记忆能力有关。虽然胆碱能神经元功能障碍与年龄相关的记忆力下降密切相关，但对于共同分布的 GABA 能投射神经元的年龄相关变化如何导致海马依赖性空间学习能力下降的了解却少之又少。在当前的研究中，使用共聚焦体视学来量化年轻和老年大鼠的头侧基底前脑中的胆碱能（胆碱乙酰转移酶（ChAT）免疫阳性）神经元、GABA能投射（谷氨酸脱羧酶67（GAD67）免疫阳性）神经元和总（NeuN免疫阳性）神经元，这些神经元首先在空间学习任务中进行表征。老年大鼠中 ChAT 免疫阳性神经元显着但适度减少。尽管 ChAT 免疫阳性神经元数量与年轻大鼠的空间学习能力密切相关，但 ChAT 免疫阳性神经元的减少与老年大鼠的空间学习能力受损无关。相比之下，在空间学习受损的老年大鼠中，GAD67 免疫阳性神经元的数量显着且选择性地增加。有趣的是，无论认知状态如何，年轻和老年大鼠的头侧基底前脑神经元总数相当。这些数据表明，年龄对表型不同的基底前脑投射神经元有不同的影响，并暗示胆碱能和 GABA 能隔海马回路失调与年龄相关的记忆力下降。
Both cholinergic and GABAergic projections from the rostral basal forebrain have been implicated in hippocampal function and mnemonic abilities. While dysfunction of cholinergic neurons has been heavily implicated in age-related memory decline, significantly less is known regarding how age-related changes in co-distributed GABAergic projection neurons contribute to a decline in hippocampal-dependent spatial learning. In the current study, confocal stereology was used to quantify cholinergic (choline acetyltransferase (ChAT) immunopositive) neurons, GABAergic projection (glutamic decarboxylase 67 (GAD67) immunopositive) neurons, and total (NeuN immunopositive) neurons in the rostral basal forebrain of young and aged rats that were first characterized on a spatial learning task. ChAT immunopositive neurons were significantly but modestly reduced in aged rats. Although ChAT immunopositive neuron number was strongly correlated with spatial learning abilities among young rats, the reduction of ChAT immunopositive neurons was not associated with impaired spatial learning in aged rats. In contrast, the number of GAD67 immunopositive neurons was robustly and selectively elevated in aged rats that exhibited impaired spatial learning. Interestingly, the total number of rostral basal forebrain neurons was comparable in young and aged rats, regardless of their cognitive status. These data demonstrate differential effects of age on phenotypically distinct rostral basal forebrain projection neurons, and implicate dysregulated cholinergic and GABAergic septohippocampal circuitry in age-related mnemonic decline.
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影响因子：
3.3
作者：
BRASHEAR, HR;ZABORSZKY, L;HEIMER, L
通讯作者：
HEIMER, L
影响因子：
1.9
作者：
BAXTER, MG;BUCCI, DJ;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
4.2
作者：
ARMSTRONG, DM;SHEFFIELD, R;GAGE, FH
通讯作者：
GAGE, FH
影响因子：
2.9
作者：
ALTAVISTA, MC;ROSSI, P;ALBANESE, A
通讯作者：
ALBANESE, A
影响因子：
4.2
作者：
Cheng, CM;Hicks, K;Bondy, CA
通讯作者：
Bondy, CA