A model framework to estimate impact and cost of genetics-based sterile insect methods for dengue vector control.
A model framework to estimate impact and cost of genetics-based sterile insect methods for dengue vector control.
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DOI：
10.1371/journal.pone.0025384
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Bonsall MB
中科院分区：
文献类型：
--
作者：
Alphey N;Alphey L;Bonsall MB
病媒传播的疾病造成巨大的健康和经济负担，显然需要采取更多的方法来控制病媒种群。昆虫不育技术（SIT）已经成功地对付了农业害虫，但还没有大规模地用于抑制或消灭蚊子种群。遗传RIDL技术（释放携带显性致死基因的昆虫）是一种拟议的修改，涉及释放昆虫是纯合的抑制性显性致死基因构建体，而不是通过辐射灭菌，并可能克服一些技术困难与传统的SIT技术。以虫媒病毒病登革热为例，我们结合联合收割机媒介种群动力学和流行病学模型，探讨RIDL释放程序对疾病传播的影响。我们使用这些来获得一个初步估计的潜在的成本效益的矢量控制应用估计的成本SIT。我们预测，这种遗传控制策略可以迅速从人类社区中消除登革热，而且费用（每例避免的病例约为2.30美元）低于疾病的直接和间接费用（每例登革热平均为86-190美元）。该理论框架具有更广泛的潜在用途;通过适当调整或替换该框架的每一个组成部分（昆虫学、流行病学、病媒控制生物经济学和卫生经济学），它可以适用于其他病媒传播疾病或病媒控制战略，并扩展到包括其他卫生干预措施。
Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populations are clearly needed. The Sterile Insect Technique (SIT) has been successful against agricultural pests, but is not in large-scale use for suppressing or eliminating mosquito populations. Genetic RIDL technology (Release of Insects carrying a Dominant Lethal) is a proposed modification that involves releasing insects that are homozygous for a repressible dominant lethal genetic construct rather than being sterilized by irradiation, and could potentially overcome some technical difficulties with the conventional SIT technology. Using the arboviral disease dengue as an example, we combine vector population dynamics and epidemiological models to explore the effect of a program of RIDL releases on disease transmission. We use these to derive a preliminary estimate of the potential cost-effectiveness of vector control by applying estimates of the costs of SIT. We predict that this genetic control strategy could eliminate dengue rapidly from a human community, and at lower expense (approximately US$ 2∼30 per case averted) than the direct and indirect costs of disease (mean US$ 86–190 per case of dengue). The theoretical framework has wider potential use; by appropriately adapting or replacing each component of the framework (entomological, epidemiological, vector control bio-economics and health economics), it could be applied to other vector-borne diseases or vector control strategies and extended to include other health interventions.
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DOI：
10.1073/pnas.1000251107
发表时间：
2010-03-09
影响因子：
11.1
作者：
Fu, Guoliang;Lees, Rosemary S.;Alphey, Luke
通讯作者：
Alphey, Luke
影响因子：
46.9
作者：
Fu, Guoliang;Condon, Kirsty C.;Alphey, Luke
通讯作者：
Alphey, Luke
影响因子：
46.9
作者：
Gong, P;Epton, MJ;Alphey, L
通讯作者：
Alphey, L
影响因子：
2.1
作者：
DAY, JF;EDEMAN, JD;SCOTT, TW
通讯作者：
SCOTT, TW
影响因子：
5
作者：
Endy, TP;Chunsuttiwat, S;Ennis, FA
通讯作者：
Ennis, FA