The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.
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DOI：
10.1126/science.1251414
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发表时间：
2014-05-09
期刊：
影响因子：
--
通讯作者：
Taylor PR
中科院分区：
文献类型：
--
作者：
Rosas M;Davies LC;Giles PJ;Liao CT;Kharfan B;Stone TC;O'Donnell VB;Fraser DJ;Jones SA;Taylor PR
Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6-deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.
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影响因子：
30.5
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影响因子：
3
作者：
Clausen, BE;Burkhardt, C;Förster, I
通讯作者：
Förster, I
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影响因子：
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作者：
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