Morpho-physiological criteria divide dentate gyrus interneurons into classes.
Morpho-physiological criteria divide dentate gyrus interneurons into classes.
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DOI：
10.1002/hipo.22214
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发表时间：
2014-02
期刊：
影响因子：
3.5
通讯作者：
Bartos, Marlene
中科院分区：
文献类型：
--
作者：
Hosp, Jonas A.;Strueber, Michael;Yanagawa, Yuchio;Obata, Kunihiko;Vida, Imre;Jonas, Peter;Bartos, Marlene
GABA能抑制性神经元控制神经元网络功能的基本方面但是，中间神经元表现出高度的形态和物理异质性。以及在这里不清楚的是Gabaergic细胞类型的连续um，我们可以在这里尚不清楚地描述dentate Gyrus的详细形态和物理表征，这是在这里详细介绍的。和有效的采样和分类，我们使用了表达增强的绿色荧光蛋白（EGFP）的敲入小鼠67中的绿色荧光蛋白（EGFP） （GAD67） - 阳性神经元和进行聚类分析。在功能上不同的类别可以控制神经元网络活动由Wiley Wendericals，Inc。出版
GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets. Indeed, interneurons display a high degree of morphological and physiological heterogeneity. However, whether their morphological and physiological characteristics are correlated and whether interneuron diversity can be described by a continuum of GABAergic cell types or by distinct classes has remained unclear. Here we perform a detailed morphological and physiological characterization of GABAergic cells in the dentate gyrus, the input region of the hippocampus. To achieve an unbiased and efficient sampling and classification we used knock-in mice expressing the enhanced green fluorescent protein (eGFP) in glutamate decarboxylase 67 (GAD67)-positive neurons and performed cluster analysis. We identified five interneuron classes, each of them characterized by a distinct set of anatomical and physiological parameters. Cross-correlation analysis further revealed a direct relation between morphological and physiological properties indicating that dentate gyrus interneurons fall into functionally distinct classes which may differentially control neuronal network activity. © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
Freund, TF