The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.
The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.
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DOI：
10.1016/j.psyneuen.2017.04.017
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发表时间：
2017-09
影响因子：
3.7
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Carol EE;Spencer RL;Mittal VA
最近的研究假设了大麻使用与生物应激系统之间的关系，但这种关键关系尚未在精神病发作前的超高风险（UHR）期间进行评估。收集了46名UHR青少年和29名对照青少年的唾液皮质醇样本；通过尿检和自我报告来评估这些人目前的大麻使用情况。UHR参与者被分为两组：目前使用大麻（UHR- cu）和目前不使用大麻（UHR- nc）。健康对照的参与者没有使用大麻。与文献一致，结果表明，与HC参与者相比，UHR个体的皮质醇水平升高。此外，我们还观察到，与不使用UHR和HC组相比，UHR- cu参与者的水平都有所升高。研究结果表明，大麻使用可能与与下丘脑-垂体-肾上腺（HPA）轴系统相关的潜在生物脆弱性相互作用。
Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine panel and self-report. UHR participants where separated into two groups: Current Cannabis Use (UHR-CU) and No Current Cannabis Use (UHR-NC). Healthy Control participants (HC) were free of cannabis use. Consistent with the literature, results indicate UHR individuals showed elevated cortisol levels when compared to HC participants. Further, we also observed that UHR-CU participants exhibited elevated levels when compared to both the non-using UHR and HC groups. Findings suggest that cannabis use may interact with underlying biological vulnerability associated with the hypothalamic-pituitary-adrenal (HPA) axis system.
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