Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
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DOI：
10.1084/jem.20080601
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发表时间：
2009-02-16
期刊：
影响因子：
--
通讯作者：
Iwasaki A
中科院分区：
文献类型：
--
作者：
Lee HK;Zamora M;Linehan MM;Iijima N;Gonzalez D;Haberman A;Iwasaki A
虽然粘膜表面是病原体进入的主要入口，但巡视各种粘膜组织的树突状细胞(DC)的抗原提呈机制尚不清楚。相反，许多工作都集中在了解注射所产生的针对抗原的免疫反应的启动。我们研究了在针头注射、皮肤表面感染或阴道黏膜单纯疱疹病毒(HSV)1感染后，迁移性和淋巴结居留DC群体在抗原呈递给CD4和CD8T细胞方面的贡献。我们发现，注射HSV-1后，HSV-1通过淋巴传播，并由常驻淋巴的树突状细胞迅速呈现给CD4和CD8T细胞。相反，经阴道感染HSV-1后，抗原主要由组织来源的移行DC呈延迟动力学递送。此外，与皮下感染相比，移行DC在阴道感染后与HSV特异性T细胞接触的频率更高。因此，迁徙DC和常驻DC在启动CD8和CD4T细胞应答中都起着重要作用，它们的相对重要性取决于体内感染的方式。
Although mucosal surfaces represent the main portal of entry for pathogens, the mechanism of antigen presentation by dendritic cells (DCs) that patrol various mucosal tissues remains unclear. Instead, much effort has focused on the understanding of initiation of immune responses generated against antigens delivered by injection. We examined the contributions of migratory versus lymph node–resident DC populations in antigen presentation to CD4 and CD8 T cells after needle injection, epicutaneous infection, or vaginal mucosal herpes simplex virus (HSV) 1 infection. We show that upon needle injection, HSV-1 became lymph-borne and was rapidly presented by lymph node–resident DCs to CD4 and CD8 T cells. In contrast, after vaginal HSV-1 infection, antigens were largely presented by tissue-derived migrant DCs with delayed kinetics. In addition, migrant DCs made more frequent contact with HSV-specific T cells after vaginal infection compared with epicutaneous infection. Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo.
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DOI：
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发表时间：
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期刊：
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影响因子：
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2000-12-18
期刊：
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影响因子：
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