Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI.
Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI.
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DOI：
10.1016/j.nlm.2013.07.006
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发表时间：
2013-11
影响因子：
2.7
通讯作者：
Thiels, Edda
中科院分区：
文献类型：
--
作者：
Wagner, Amy K.;Brayer, Samuel W.;Hurwitz, Max;Niyonkuru, Christian;Zou, Huichao;Failla, Michelle;Arenth, Patricia;Manole, Mioara D.;Skidmore, Elizabeth;Thiels, Edda
关键词：
存在外显和内隐学习和记忆网络，其中每个网络可以促进或抑制记忆。临床证据表明，创伤性脑损伤（TBI）后内隐网络相对保留。非空间预训练（NSPT）在Morris水迷宫（MWM）中提供了完成任务所必需的行为成分，同时限制了空间地图的形成。我们的研究利用MWM中的NSPT来评估TBI的受控皮质撞击（CCI）模型中的内隐和外显学习和记忆系统缺陷。将76只成年雄性Sprague-Dawley大鼠分为：CCI组与假手术组、NSPT组与无NSPT组以及提示组与非提示组。手术前4天发生NSPT（动态隐藏平台位置，迷宫外线索覆盖，静态池入口点）。采集（d14-18）、探针/可见平台（d19）和反射（d20-21）试验在有或没有额外迷宫线索的情况下进行。使用了新的时间分配和搜索策略选择指标。结果表明，内隐和外显学习/记忆网络在MWM中是可区分的。在提示条件下，NSPT减少趋触性，改善位置学习，并在很大程度上消除了明显的损伤诱导的赤字通常观察到未经训练的CCI和假手术大鼠之间。然而，在NSPT组中，与假手术相比，CCI大鼠将线索纳入搜索策略选择的能力相对受损。非提示条件下的表现显示假手术/NSPT和CCI/NSPT大鼠表现相似，表明CCI后2周内隐记忆网络基本完整。与未经训练的对照组相比，CCI/NSPT和假手术/NSPT大鼠之间的位置学习差异更准确地反映了我们的CCI模型中的空间缺陷。这些数据表明，NSPT作为一种临床相关的结构，用于评估潜在的神经恢复和神经保护治疗。这些发现也支持非空间认知训练范式的发展，用于评估康复相关的组合疗法。
Explicit and implicit learning and memory networks exist where each network can facilitate or inhibit memory. Clinical evidence suggests that implicit networks are relatively preserved after traumatic brain injury (TBI). Non-spatial pre-training (NSPT) in the Morris water maze (MWM) provides the necessary behavioral components to complete the task, while limiting the formation of spatial maps. Our study utilized NSPT in the MWM to assess implicit and explicit learning and memory system deficits in the controlled cortical impact (CCI) model of TBI. 76 adult male Sprague-Dawley rats were divided: CCI vs. sham surgery, NSPT vs. No-NSPT, and cued vs. non-cued groups. NSPT occurred for 4d prior to surgery (dynamic hidden platform location, extra-maze cues covered, static pool entry point). Acquisition (d14–18), Probe/Visible Platform (d19), and Reversal (d20–21) trials were conducted with or without extra-maze cues. Novel time allocation and search strategy selection metrics were utilized. Results indicated implicit and explicit learning/memory networks are distinguishable in the MWM. In the cued condition, NSPT reduced thigmotaxis, improved place learning, and largely eliminated the apparent injury-induced deficits typically observed between untrained CCI and sham rats. However, among NSPT groups, incorporation of cues into search strategy selection for CCI rats was relatively impaired compared to shams. Non-cued condition performance showed sham/NSPT and CCI/NSPT rats perform similarly, suggesting implicit memory networks are largely intact 2 weeks after CCI. Place learning differences between CCI/NSPT and sham/NSPT rats more accurately reflect spatial deficits in our CCI model compared to untrained controls. These data suggest NSPT as a clinically relevant construct for evaluating potential neurorestorative and neuroprotective therapies. These findings also support development of non-spatial cognitive training paradigms for evaluating rehabilitation relevant combination therapies.
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影响因子：
4.2
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通讯作者：
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