Evidence from an fMRI study that dessert-flavored e-cigarettes engage taste-related, but not smoking-related, brain circuitry for female daily smokers.
Evidence from an fMRI study that dessert-flavored e-cigarettes engage taste-related, but not smoking-related, brain circuitry for female daily smokers.
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DOI：
10.1037/pha0000488
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发表时间：
2022-12
影响因子：
2.3
通讯作者：
Yang QX
中科院分区：
文献类型：
--
作者：
Hobkirk AL;Houser KR;Hoglen B;Bitzer ZT;Fendrich A;Bordner CR;Foulds J;Wang J;Mukherjee D;Yingst JM;Karunanayaka P;Goel R;Richie JP;Elias RJ;Yang QX
限制调味电子烟产品销售的法规存在争议，因为它们除了抑制青少年使用外，还可能干扰电子烟作为戒烟辅助手段的使用。有限的研究表明，味道可能会增强电子烟的成瘾潜力;然而，调味气溶胶对人类大脑功能的急性影响尚未得到评估。目前的研究旨在分离和比较9名女性每日吸烟者中调味和非调味电子烟气溶胶对脑功能的神经基质。参与者在进行功能性磁共振成像时，吸入含有36 mg/ml尼古丁的雾化电子液体，有或没有草莓香草味。我们使用一般线性建模来比较全脑平均神经激活和基于种子到体素任务的功能连接之间的调味和无味吸入运行。与我们的假设相反，调味气溶胶与脑干和双侧顶颞枕皮质区的激活比无味气溶胶弱。相反，这种味道参与了与味道相关的大脑区域，同时抑制了通常在吸烟和尼古丁给药期间参与的神经回路的激活。或者，皮质下多巴胺能脑种子和皮质脑区域参与动机和奖励显着性之间的功能连接更强的风味相比，无味的气雾剂运行。研究结果表明，水果和甜点口味的电子烟可能会通过抑制多巴胺能脑回路的激活来抑制开始使用电子烟的吸烟者的雾化吸入奖励体验。这些初步研究结果可能对了解调味电子烟的法规如何影响其作为戒烟辅助手段的使用具有影响。
Regulations limiting the sale of flavored e-cigarette products are controversial for their potential to interfere with e-cigarette use as a cessation aid in addition to curbing youth use. Limited research suggests that flavor might enhance the addictive potential of e-cigarettes; however, the acute effects of flavored aerosols on brain function among humans has not been assessed. The current study aimed to isolate and compare the neural substrates of flavored and unflavored e-cigarette aerosols on brain function among nine female daily smokers. Participants inhaled aerosolized e-liquid with 36 mg/ml of nicotine with and without a strawberry-vanilla flavor while undergoing functional magnetic resonance imaging. We used general linear modelling to compare whole-brain mean neural activation and seed-to-voxel task-based functional connectivity between the flavored and unflavored inhalation runs. Contrary to our hypothesis, the flavored aerosol was associated with weaker activation than the unflavored aerosol in the brain stem and bilateral parietal-temporal-occipital region of the cortex. Instead, the flavor engaged taste-related brain regions while suppressing activation of the neural circuits typically engaged during smoking and nicotine administration. Alternatively, functional connectivity between subcortical dopaminergic brain seeds and cortical brain regions involved in motivation and reward salience were stronger during the flavored compared to unflavored aerosol run. The findings suggest that fruity and dessert-flavored e-cigarettes may dampen the reward experience of aerosol inhalation for smokers who initiate e-cigarette use by inhibiting activation of dopaminergic brain circuits. These preliminary findings may have implications for understanding how regulations on flavored e-cigarettes might impact their use as cessation aids.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.3390/molecules25184223
发表时间：
2020-09-15
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Cooper SY;Henderson BJ
通讯作者：
Henderson BJ
影响因子：
3.2
作者：
Laird AR;Fox PM;Eickhoff SB;Turner JA;Ray KL;McKay DR;Glahn DC;Beckmann CF;Smith SM;Fox PT
通讯作者：
Fox PT
影响因子：
4.7
作者：
Megerdichian, Christine L.;Rees, Vaughan W.;Connolly, Gregory N.
通讯作者：
Connolly, Gregory N.
影响因子：
5.6
作者：
Kroemer, Nils B.;Veldhuizen, Maria G.;Small, Dana M.
通讯作者：
Small, Dana M.