Infant mortality, season of birth and the health of older Puerto Rican adults.
Infant mortality, season of birth and the health of older Puerto Rican adults.
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DOI：
10.1016/j.socscimed.2010.08.026
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发表时间：
2011-03
影响因子：
5.4
通讯作者：
McEniry, Mary
中科院分区：
文献类型：
--
作者：
McEniry, Mary
关键词：
低收入和中等收入国家老龄人口中心脏病和糖尿病的患病率日益增加，这导致人们对内源性早期暴露（子宫内暴露）在多大程度上是这些健康状况的重要决定因素提出了疑问。我们设计了一个使用婴儿死亡率（IMR）的测试，以验证出生季节是否是早期生命（子宫内）条件的良好指标，这些条件会促使成年人发病。我们使用来自波多黎各老年人：健康状况（PREHCO）研究的老年波多黎各成年人（n=1447）的代表性样本，将20世纪20年代末至40年代初市（municipio）一级的年度婴儿死亡率（IMR）与个人出生年份和地点联系起来。然后，我们估计了出生季节对所有受访者的成年心脏病和糖尿病的影响，然后根据他们是否出生时IMR较低或较高，控制年龄，性别，肥胖，受访者的教育水平，成年行为（吸烟和锻炼）和其他早期生活暴露（儿童健康，膝盖高度和儿童社会经济地位（SES））。影响的模式表明，出生季节反映了内源性原因：（1）在IMR较低的年份，心脏病和糖尿病的几率对于那些在淡季出生的人来说很强，而且很重要;（2）即使在控制了其他儿童条件和成人行为之后，影响仍然一致;但（3）对于IMR较高的成年人来说，成年健康没有季节性影响。我们的结论是，在这个人口的老年波多黎各成年人有持续的支持，如营养不良和传染病的不良内源性（在子宫内）条件的时间可能与成人心脏病和糖尿病。在发展中国家的其他类似人群中检验这些发现的有效性将是重要的。
The increasing prevalence of heart disease and diabetes among aging populations in low and middle income countries leads to questions regarding the degree to which endogenous early life exposures (exposures in utero) are important determinants of these health conditions. We devised a test using infant mortality (IMR) to verify if season of birth is a good indicator of early life (in utero) conditions that precipitate adult onset of disease. We linked annual infant mortality (IMR) at the municipality (municipio) level from the late 1920s-early 1940s with individual birth year and place using a representative sample of older Puerto Rican adults (n=1447) from the Puerto Rican Elderly: Health Conditions (PREHCO) study. We then estimated the effects of season of birth on adult heart disease and diabetes for all respondents and then for respondents according to whether they were born when IMR was lower or higher, controlling for age, gender, obesity, respondent’s educational level, adult behavior (smoking and exercise) and other early life exposures (childhood health, knee height and childhood socioeconomic status (SES)). The pattern of effects suggests that season of birth reflects endogenous causes: (1) odds of heart disease and diabetes were strong and significant for those born during the lean season in years when IMR was lower; (2) effects remained consistent even after controlling for other childhood conditions and adult behavior; but (3) no seasonality effects on adult health for adults born when IMR was higher. We conclude that in this population of older Puerto Rican adults there is continued support that the timing of adverse endogenous (in utero) conditions such as poor nutrition and infectious diseases may be associated with adult heart disease and diabetes. It will be important to test the validity of these findings in other similar populations in the developing world.
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影响因子：
1.5
作者：
Hodrick, RJ;Prescott, EC
通讯作者：
Prescott, EC
DOI：
10.1073/pnas.0510567103
发表时间：
2006-01-31
影响因子：
11.1
作者：
Catalano, R;Bruckner, T
通讯作者：
Bruckner, T
影响因子：
2.4
作者：
Bengtsson, T;Lindström, M
通讯作者：
Lindström, M
影响因子：
7.2
作者：
Goldman, N;Lin, IF;Lin, YH
通讯作者：
Lin, YH
影响因子：
7.7
作者：
Bengtsson, T;Lindström, M
通讯作者：
Lindström, M