Shining light on skin pigmentation: the darker and the brighter side of effects of UV radiation.
Shining light on skin pigmentation: the darker and the brighter side of effects of UV radiation.
复制标题
皮肤色素沉着的光闪亮：紫外线辐射效应的较暗和较明亮的一面。
DOI：
10.1111/j.1751-1097.2012.01138.x
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发表时间：
2012-09
影响因子：
3.3
通讯作者：
Setaluri V
中科院分区：
文献类型：
--
作者：
Maddodi N;Jayanthy A;Setaluri V
“屏障功能”一词应用于人体皮肤，通常意味着该器官的物理特性，即提供保护，使其免受周围环境的影响。这个术语一般不包括皮肤色素沉着。然而，皮肤色素沉着也具有同样重要的保护功能，这是皮肤底层黑色素细胞产生黑色素并输出到上层角质形成细胞的结果。事实上，皮肤色素沉着的变化往往是皮肤暴露于有害物质，特别是环境中自然和人工辐射的最容易识别的指标。最近的几项研究揭示了以下方面的新情况：a)紫外线辐射亚组分对人类皮肤色素沉着的选择性作用所涉及的机制；b)作为“表皮黑色素单位”的角化细胞和黑素细胞之间的相互作用影响，表现为暴露于各种形式的辐射后皮肤色素沉着的变化。本文简要回顾了我们目前对非电离太阳辐射在细胞和分子水平上对人类皮肤色素沉着的影响的理解。
The term barrier function as applied to human skin often connotes the physical properties of this organ that provide protection from its surrounding environment. This term does not generally include skin pigmentation. However, skin pigmentation, which is the result of melanin produced in melanocytes residing the basal layer of the skin and exported to the keratinocytes in the upper layers, serves equally important protective function. Indeed, changes in skin pigmentation are often the most readily recognized indicators of exposure of skin to damaging agents, especially to natural and artificial radiation in the environment. Several recent studies have shed new light on a) the mechanisms of involved in selective effects of subcomponents of UV radiation on human skin pigmentation and b) the interactive influences between keratinocytes and melanocytes, acting as ‘epidermal melanin unit’, that manifest as changes in skin pigmentation in response to exposure to various forms of radiation. This article provides a concise review of our current understanding of the effects of the non-ionizing solar radiation, at cellular and molecular levels, on human skin pigmentation.
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影响因子：
4
作者：
Choi, Wonseon;Wolber, Rainer;Hearing, Vincent J.
通讯作者：
Hearing, Vincent J.
影响因子：
64.5
作者：
Cui, Rutao;Widlund, Hans R.;Fisher, David E.
通讯作者：
Fisher, David E.
影响因子：
3.6
作者：
Asuquo, Maurice E.;Ngim, Ogbu;Bassey, Ekpo E.
通讯作者：
Bassey, Ekpo E.
DOI：
10.1034/j.1600-0781.2002.180204.x
发表时间：
2002-04-01
影响因子：
2.6
作者：
Hönigsmann, H
通讯作者：
Hönigsmann, H
影响因子：
6
作者：
Hachiya, A;Kobayashi, A;Imokawa, G
通讯作者：
Imokawa, G