Neurotrophic factors and corneal nerve regeneration.
Neurotrophic factors and corneal nerve regeneration.
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DOI：
10.4103/1673-5374.213534
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发表时间：
2017-08
影响因子：
6.1
通讯作者：
Lambiase A
中科院分区：
文献类型：
--
作者：
Sacchetti M;Lambiase A
角膜具有独特的功能，使其成为再生医学研究的有用模型。它是一种无血管、透明、神经支配密集的组织，任何病理变化都可以通过裂隙灯检查轻易发现。角膜敏感性由三叉神经的眼分支提供，其激发保护性反射，例如眨眼和流泪，并通过释放神经介质和生长因子来施加营养支持。使用标准仪器如角膜触觉计和体内共聚焦显微镜，可以很容易地评估角膜神经的功能和形态。所有与三叉神经损伤相关的局部和全身性疾病都会导致神经营养性角膜炎，这是一种罕见的退行性疾病。神经营养性角膜炎的特征在于与持续上皮缺损的发展相关的角膜敏感性受损，所述持续上皮缺损可进展为角膜溃疡、熔化和穿孔。目前的神经营养性角膜炎治疗旨在支持角膜愈合和预防角膜损伤的进展。能够刺激角膜神经恢复的新型化合物处于高级开发阶段。其中，神经生长因子滴眼液在促进神经营养性角膜炎患者的角膜愈合和改善角膜敏感性方面显示出安全有效。神经营养性角膜炎是一个有用的模型，以评估在临床实践中的新的神经再生药物。
The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors. Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer, melting and perforation. Current neurotrophic keratitis treatments aim at supporting corneal healing and preventing progression of corneal damage. Novel compounds able to stimulate corneal nerve recovery are in advanced development stage. Among them, nerve growth factor eye drops showed to be safe and effective in stimulating corneal healing and improving corneal sensitivity in patients with neurotrophic keratitis. Neurotrophic keratitis represents an useful model to evaluate in clinical practice novel neuro-regenerative drugs.
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DOI：
10.1016/j.jtos.2016.09.004
发表时间：
2017-01
期刊：
The ocular surface
影响因子：
--
作者：
Cruzat A;Qazi Y;Hamrah P
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DOI：
10.1007/bf00165937
发表时间：
1992-07-01
影响因子：
2.7
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9.9
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2.8
作者：
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影响因子：
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作者：
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