Toxoplasma gondii seropositivity and co-infection with TORCH pathogens in high-risk patients from Qatar.
Toxoplasma gondii seropositivity and co-infection with TORCH pathogens in high-risk patients from Qatar.
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卡塔尔高危患者弓形虫血清阳性和 TORCH 病原体合并感染。
DOI：
10.4269/ajtmh.2010.09-0530
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Dabritz HA
中科院分区：
文献类型：
--
作者：
Abu-Madi MA;Behnke JM;Dabritz HA
检测被认为具有TORCH病原体高风险的患者，例如孕妇、其胎儿、新生儿和获得性免疫缺陷综合征（艾滋病）患者，对于启动特异性治疗非常重要。这项研究在2005年至2008年间纳入了1857名这样的患者。采用Logistic回归评价与刚地弓形虫血清阳性相关的因素。823名育龄妇女中，弓形虫IgG和IgM阳性分别为35.1%和5.2%。3名≤6个月的婴儿（353人中0.8%）为先天性感染。与弓形虫IgG血清阳性相关的因素包括年龄较大、东地中海或非洲国籍、巨细胞病毒（CMV）和单纯疱疹病毒(HSV)-1血清阳性、风疹IgG阴性。2005年至2008年间IgM抗体流行率的下降表明，卡塔尔在此期间从食物或环境来源暴露于弓形虫的情况有所下降。以人口为基础的新生儿研究将有助于准确估计先天性弓形虫病的发病率。
Testing of patients who are deemed to be at high risk for TORCH pathogens, e.g., pregnant women, their fetuses, neonates, and acquired immunodeficiency syndrome (AIDS) patients, is important so that specific treatment can be initiated. This study included 1,857 such patients between 2005 and 2008. Logistic regression was used to evaluate factors associated with Toxoplasma gondii seropositivity. Among 823 women of childbearing age, 35.1% and 5.2% tested positive for T. gondii IgG and IgM, respectively. Three infants ≤ 6 months of age (0.8% of 353) were congenitally infected. Factors associated with T. gondii IgG seropositivity included older age, East Mediterranean or African nationality, positive cytomegalovirus (CMV) and herpes simplex virus (HSV)-1 serostatus, and negative rubella IgG results. The decreasing prevalence of IgM antibodies between 2005 and 2008 suggested that exposure to T. gondii from food or environmental sources declined over this period in Qatar. Population-based studies of newborns would be helpful to accurately estimate incidence of congenital toxoplasmosis.
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影响因子：
11.8
作者：
de Moura L;Bahia-Oliveira LM;Wada MY;Jones JL;Tuboi SH;Carmo EH;Ramalho WM;Camargo NJ;Trevisan R;Graça RM;da Silva AJ;Moura I;Dubey JP;Garrett DO
通讯作者：
Garrett DO
影响因子：
3.2
作者：
Abu-Madi, Marawan A.;Al-Molawi, Naema;Behnke, Jerzy M.
通讯作者：
Behnke, Jerzy M.
影响因子：
2.6
作者：
Dubey, JP
通讯作者：
Dubey, JP
影响因子：
7.7
作者：
ALNAKIB, W;IBRAHIM, MEA;YOUSOF, AM
通讯作者：
YOUSOF, AM
影响因子：
2.1
作者：
BOBIC, B;SIBALIC, D;DJURKOVICDJAKOVIC, O
通讯作者：
DJURKOVICDJAKOVIC, O