Seroprevalence and epidemiological correlates of Toxoplasma gondii infections among patients referred for hospital-based serological testing in Doha, Qatar.
Seroprevalence and epidemiological correlates of Toxoplasma gondii infections among patients referred for hospital-based serological testing in Doha, Qatar.
复制标题
DOI：
10.1186/1756-3305-1-39
复制
发表时间：
2008-10-20
影响因子：
3.2
通讯作者：
Behnke, Jerzy M.
中科院分区：
文献类型：
--
作者：
Abu-Madi, Marawan A.;Al-Molawi, Naema;Behnke, Jerzy M.
卡塔尔多哈市野猫密度高，居民感染弓形体病的风险很高。目前尚无该市弓形虫感染流行率的数据。我们分析了 1625 名在卡塔尔多哈进行常规医院血清学检测的受试者对弓形虫的血清学反应。通过酶联免疫吸附测定 (ELISA) 评估当前/近期感染的患病率，以确定是否存在特异性抗 T 细胞。弓形虫 IgM 抗体，以及既往 IgG 感染史。 IgG 反应的总体患病率为 29.8%，尽管存在明显的年龄效应，但在性别之间以及研究的三年之间没有差异。在 1 岁以下儿童中，患病率为 22.9%，但在 1 岁儿童组中，患病率降至 <4%，这表明这些抗体很可能是在子宫内从免疫母亲那里获得的。然后，在最高年龄段（> 45 岁）中，患病率稳步上升，达到峰值 41.2%。 IgG 抗体的患病率也因来源地区的不同而存在显着差异，来自非洲的受试者的患病率较高，其次是来自东地中海或亚洲的受试者，来自阿拉伯半岛的受试者的患病率最低。在 19 岁以下的受试者中未检测到 IgM 抗体，但在 20 岁以上的受试者中，患病率上升至 7-9% 的稳定水平，并且随来源地区的不同而变化。在这种情况下，阿拉伯半岛的患病率最高，亚洲的患病率最低。男性受试者中 IgM 的患病率较高，但在三年的研究中没有变化。尽管这些数据是基于选定的人口子集，但它们仍然提供了第一个证据，证明弓形体病在卡塔尔人群中流行，并且年龄和起源地区在感染的流行病学中发挥着作用。人们强调了与高密度野猫在维持感染方面的作用有关的担忧。
The city of Doha in Qatar has a high density of feral cats and there is a high risk of toxoplasmosis for the resident human population. No data currently exist for the prevalence of infection with Toxoplasma gondii in the city. We analysed the serological response to Toxoplasma gondii of 1625 subjects referred for routine hospital based serological tests in Doha, Qatar. Prevalence of current/recent infection was assessed through an enzyme-linked immunosorbent assay (ELISA) for the presence of specific anti-T. gondii IgM antibodies, and previous history of infection through IgG. Overall prevalence of IgG responses was 29.8% and this did not differ between the sexes nor between the three years of the study although there was a marked age effect. Among children less than 1 year old prevalence was 22.9%, but then dropped to <4% in the 1 year old group, indicating that these antibodies were most likely acquired in utero from immune mothers. Prevalence then increased steadily to peak at 41.2% among the oldest age class (>45 years). The prevalence of IgG antibody also varied significantly with region of origin, with higher rates for subjects from Africa, followed by those from the Eastern Mediterranean or Asia and lowest rates for subjects from the Arabian Peninsula. No IgM antibodies were detected in any subjects younger than 19 years, but prevalence increased to plateau at 7 – 9% in subjects aged over 20 years, and also varied with region of origin. In this case prevalence was highest among subjects from the Arabian Peninsula and least among those from Asia. Prevalence of IgM was higher among male subjects but did not vary between the three years of the study. Although these data are based on a selected subset of the population, they nevertheless provide the first evidence that toxoplasmosis is endemic in Qatar in the human population, and that both age and region of origin play a role in the epidemiology of the infection. Concerns relating to the role of high density of feral cats in sustaining the infection were highlighted.
登录
查看更多内容
影响因子：
14.2
作者：
Hill, D;Dubey, JP
通讯作者：
Dubey, JP
影响因子：
1.6
作者：
Abu-Madi, M. A.;Pal, P.;Lewis, J. W.
通讯作者：
Lewis, J. W.
影响因子：
6.1
作者：
Jauniaux, E;Jurkovic, D;Campbell, S
通讯作者：
Campbell, S
影响因子：
2.6
作者：
Dubey, JP
通讯作者：
Dubey, JP
影响因子：
14.2
作者：
Diza, E;Frantzidou, F;Antoniadis, A
通讯作者：
Antoniadis, A