Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis.
Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis.
复制标题
体重指数和类风湿性关节炎的风险：系统评价和剂量反应荟萃分析
DOI：
10.1186/s13075-015-0601-x
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发表时间：
2015-03-29
影响因子：
4.9
通讯作者：
Zhong R
中科院分区：
文献类型：
--
作者：
Qin B;Yang M;Fu H;Ma N;Wei T;Tang Q;Hu Z;Liang Y;Yang Z;Zhong R
IntroductionThe evidence from published studies on the association between obesity and rheumatoid arthritis has been contradictory. To clarify the association between obesity and rheumatoid arthritis, we conducted a systematic review and dose-response meta-analysis to assess the relationship between body mass index and rheumatoid arthritis risk.MethodsA systematic literature search of PubMed and Embase (up to 12 July 2014) was performed to identify all eligible published reports. The pooled relative risk results with corresponding 95% confidence intervals of rheumatoid arthritis development were estimated using a random-effects model.ResultsEleven eligible related citations fulfilled the inclusion criteria and were included in the study. Compared with individuals with a body mass index under 30, obese individuals showed an association with a significantly increased risk of rheumatoid arthritis (relative risk = 1.25, 95% confidence interval: 1.07 to 1.45,Pheterogeneity<0.01, I2= 63%). Compared to normal weight subjects, the pooled relative risks for rheumatoid arthritis were 1.31 (1.12 to 1.53) and 1.15 (1.03 to 1.29) for the categories of obese and overweight, respectively. In the dose-response analysis, there was evidence of a nonlinear association (Pnonlinear= 0.005) and the estimated summary relative risk for a 5-unit increment was 1.03 (95% confidence interval: 1.01 to 1.05,Pheterogeneity= 0.001, I2= 70.0%).ConclusionsAn increase in body mass index can contribute to a higher risk for rheumatoid arthritis development. However, the finding also highlights the need for research on the association between body mass index and rheumatoid arthritis risk with adjustment for more confounding factors.
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影响因子：
4.7
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Davis, John M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
6.9
作者：
McTiernan, Anne;Wu, LieLing;Wang, C. Y.
通讯作者：
Wang, C. Y.
影响因子：
4.9
作者：
Di Giuseppe D;Discacciati A;Orsini N;Wolk A
通讯作者：
Wolk A
利用生活方式因素来识别炎症性多关节炎风险较高的个体（来自欧洲诺福克癌症前瞻性调查和诺福克关节炎登记册 - EPIC-2-NOAR 研究的结果）。
影响因子：
27.4
作者：
Lahiri M;Luben RN;Morgan C;Bunn DK;Marshall T;Lunt M;Verstappen SM;Symmons DP;Khaw KT;Wareham N;Bruce IN
通讯作者：
Bruce IN