Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.
Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.
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DOI：
10.1016/j.fertnstert.2012.04.012
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发表时间：
2012-07
影响因子：
6.7
通讯作者：
Hauser, Russ
中科院分区：
文献类型：
--
作者：
Chavarro, Jorge E.;Ehrlich, Shelley;Colaci, Daniela S.;Wright, Diane L.;Toth, Thomas L.;Petrozza, John C.;Hauser, Russ
评估体重指数和短期体重变化与抗逆转录病毒治疗结果的关系。前瞻性队列研究。学术医疗中心的生育中心。170名妇女接受233个抗逆转录病毒治疗周期。基线BMI和短期体重变化与ART结果相关。考虑到重复观察的回归模型被用来调整潜在混杂因素的数据。超重和肥胖与较低的出生率有关。调整后的活产率(95%CI)在BMI在20-22.4 kg/m2之间的妇女中为42%(28%-58%)，在超重或肥胖妇女中为23%(14%-36%)(p，趋势=0.03)。短期体重减轻与取回率较高的MII卵母细胞有关。体重下降3公斤或以上的女性，调整后的MII卵子比例为91%(87%-94%)，体重保持稳定的女性为86%(81%-%)(p，趋势=0.002)。这种关联在基线时超重或肥胖的女性中更强。短期体重减轻与βhCG阳性、临床妊娠率或活产率无关。在接受抗逆转录病毒治疗的女性中，超重和肥胖与较低的活产率有关。短期体重减轻与更高的MII产率有关，特别是在超重和肥胖女性中，但与临床结果无关。
To assess the relation between BMI and short-term weight change with ART outcomes. Prospective cohort study. Fertility center at an academic medical center. 170 women undergoing 233 ART cycles. Baseline BMI and short-term weight change were related to ART outcomes. Regression models accounting for repeated observations were used to adjust data for potential confounders. Overweight and obesity were associated with lower live birth rates. The adjusted live birth rate (95%CI) was 42% (28%–58%) among women with a BMI between 20 and 22.4 kg/m2 and 23% (14%–36%) among overweight or obese women (p,trend=0.03). Short-term weight loss was associated with a higher proportion of MII oocytes retrieved. The adjusted proportion of MII eggs was 91% (87%–94%) for women who lost 3kg or more and 86% (81%–89%) for women whose weight remained stable (p,trend=0.002). This association was stronger among women who were overweight or obese at baseline. Short-term weight loss was unrelated to positive βhCG, clinical pregnancy or live birth rates. Overweight and obesity were related to lower live birth rates in women undergoing ART. Short term weight loss was related to higher MII yield, particularly among overweight and obese women, but unrelated to clinical outcomes.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
6.1
作者：
Fedorcsák, P;Dale, PO;Tanbo, T
通讯作者：
Tanbo, T
影响因子：
4
作者：
Esinler, I.;Bozdag, G.;Yarali, H.
通讯作者：
Yarali, H.
影响因子：
4
作者：
Metwally, M.;Cutting, R.;Li, T. C.
通讯作者：
Li, T. C.
影响因子：
6.1
作者：
Maheshwari, Abha;Scotland, Graham;Bhattacharya, Siladitya
通讯作者：
Bhattacharya, Siladitya