Distinction of Microglia and Macrophages in Glioblastoma: Close Relatives, Different Tasks?
Distinction of Microglia and Macrophages in Glioblastoma: Close Relatives, Different Tasks?
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DOI：
10.3390/ijms22010194
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发表时间：
2020-12-27
影响因子：
5.6
通讯作者：
Vajkoczy P
中科院分区：
文献类型：
--
作者：
Brandenburg S;Blank A;Bungert AD;Vajkoczy P
几十年来，已经知道肿瘤微环境对于胶质瘤进展是重要的，即髓样细胞如小胶质细胞和巨噬细胞的浸润。因此，这些细胞类型及其在肿瘤进展中的特定任务正在进行研究。然而，脑内小胶质细胞和外周巨噬细胞在肿瘤组织中的分布及其功能活性存在很大争议。结果取决于用于区分小胶质细胞和巨噬细胞的方法，其中由于区分这两种细胞群体的选择有限，该规范已经很困难，这两种细胞群体显示出大多相同的表面标志物和形态。此外，有迹象表明小胶质细胞和巨噬细胞的各种功能，但在区分方法上又有所不同。在我们的综述中，我们总结了目前的文献，以确定哪些方法已被应用于区分脑驻留的小胶质细胞从肿瘤浸润的巨噬细胞。此外，我们收集了有关胶质瘤组织中小胶质细胞和巨噬细胞比例的数据，并确定是否可以将促肿瘤或抗肿瘤作用分配给一个或另一个髓样细胞群体。最近的研究作出了巨大的努力，以区分小胶质细胞从招募的巨噬细胞。对于未来的研究，验证这些细胞在脑肿瘤病理学中发挥的作用可能是至关重要的，以便采用新的免疫策略。
For decades, it has been known that the tumor microenvironment is significant for glioma progression, namely the infiltration of myeloid cells like microglia and macrophages. Hence, these cell types and their specific tasks in tumor progression are subject to ongoing research. However, the distribution of the brain resident microglia and the peripheral macrophages within the tumor tissue and their functional activity are highly debated. Results depend on the method used to discriminate between microglia and macrophages, whereby this specification is already difficult due to limited options to distinguish between these both cell populations that show mostly the same surface markers and morphology. Moreover, there are indications about various functions of microglia and macrophages but again varying on the method of discrimination. In our review, we summarize the current literature to determine which methods have been applied to differentiate the brain resident microglia from tumor-infiltrated macrophages. Furthermore, we compiled data about the proportion of microglia and macrophages in glioma tissues and ascertained if pro- or anti-tumoral effects could be allocated to one or the other myeloid cell population. Recent research made tremendous efforts to distinguish microglia from recruited macrophages. For future studies, it could be essential to verify which role these cells play in brain tumor pathology to proceed with novel immunotherapeutic strategies.
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影响因子：
7.3
作者：
Amici SA;Dong J;Guerau-de-Arellano M
通讯作者：
Guerau-de-Arellano M
影响因子：
6
作者：
Abe N;Nishihara T;Yorozuya T;Tanaka J
通讯作者：
Tanaka J
影响因子：
10.5
作者：
Amankulor NM;Kim Y;Arora S;Kargl J;Szulzewsky F;Hanke M;Margineantu DH;Rao A;Bolouri H;Delrow J;Hockenbery D;Houghton AM;Holland EC
通讯作者：
Holland EC
影响因子：
5.8
作者：
Azambuja, J. H.;Schuh, R. S.;Braganhol, E.
通讯作者：
Braganhol, E.
影响因子：
2.5
作者：
Badie, B;Schartner, J
通讯作者：
Schartner, J