Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.
Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.
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DOI：
10.1002/jmv.24836
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发表时间：
2017-11
影响因子：
12.7
通讯作者：
King CC
中科院分区：
文献类型：
--
作者：
Blackard JT;Ma G;Welge JA;Taylor LE;Mayer KH;Klein RS;Celentano DD;Sobel JD;Jamieson DJ;King CC
人类Pegivirus（HPgV）-以前称为GB病毒C（GBV-C）-对HIV疾病进展的有益影响以前已有报道。HPgV抑制HIV复制的一种可能机制是细胞因子/趋化因子环境的改变。尽管它们对疾病进展的影响和表达中基于性别的差异的可能性，但尚未在女性中专门评估它们的表达。此外，HPgV基因型对细胞因子/趋化因子表达的影响是未知的。在150名基于HPgV RNA状态的HIV阳性妇女中定量IL-2、IL-4、IL-7、IL-8、IL-10、IL-12 p70、IL-13、IFNγ、TNFα、IP-10、MIP-1α、MIP-1β和TGF-β1的血清水平。检测率至少为50%的细胞因子/趋化因子包括IL-2、IL-4、IL-8、IL-10、IL-12 p70、IFNγ、TNFα、IP-10、MIP-1α、MIP-1β和TGF-β1。对于IL-7、IL-13、IL-12 p70和IFNγ，HPgV阳性女性的绝对值显著高于HPgV阴性女性。HPgV阳性女性的IL-4、IL-8、TGF-β1和IP-10的绝对值显著较低。HPgV基因型2的IFNγ值高于基因型1（p = 0.036）。通过HPgV对细胞因子/趋化因子调节的进一步研究可能最终导致开发新的治疗剂来治疗HIV感染和/或设计模拟HPgV复制的“保护”作用的疫苗策略。
A beneficial impact of the Human Pegivirus (HPgV) – formerly called GB virus C (GBV-C) – on HIV disease progression has been reported previously. One possible mechanism by which HPgV inhibits HIV replication is an alteration of the cytokine/chemokine milieu. Their expression has not been specifically evaluated in women despite their influence on disease progression and the possibility of gender-based differences in expression. Moreover, the impact of HPgV genotype on cytokine/chemokine expression is unknown. Sera levels of IL-2, IL-4, IL-7, IL-8, IL-10, IL-12p70, IL-13, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β1 were quantified in 150 HIV-positive women based on HPgV RNA status. Cytokines/chemokines with detection rates of at least 50% included IL-2, IL-4, IL-8, IL-10, IL-12p70, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β1. Absolute values were significantly higher for HPgV positive compared to HPgV negative women for IL-7, IL-13, IL-12p70, and IFNγ. Absolute values were significantly lower for HPgV positive women for IL-4, IL-8, TGF-β1, and IP-10. IFNγ values were higher for HPgV genotype 2 than for genotype 1 (p = 0.036). Further study of cytokine/chemokine regulation by HPgV may ultimately lead to the development of novel therapeutic agents to treat HIV infection and/or the design of vaccine strategies that mimic the ‘protective’ effects of HPgV replication.
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影响因子：
11.2
作者：
Chang CM;Stapleton JT;Klinzman D;McLinden JH;Purdue MP;Katki HA;Engels EA
通讯作者：
Engels EA
影响因子：
1.2
作者：
Schwarze-Zander C;Neibecker M;Othman S;Tural C;Clotet B;Blackard JT;Kupfer B;Luechters G;Chung RT;Rockstroh JK;Spengler U
通讯作者：
Spengler U
影响因子：
6.4
作者：
Heringlake, S;Ockenga, J;Manns, MP
通讯作者：
Manns, MP
影响因子：
3.8
作者：
Birk, M;Lindbäck, S;Lidman, C
通讯作者：
Lidman, C
影响因子：
3.8
作者：
Björkman, P;Flamholc, L;Widell, A
通讯作者：
Widell, A