Image-guided small animal radiation research platform: calibration of treatment beam alignment.
Image-guided small animal radiation research platform: calibration of treatment beam alignment.
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DOI：
10.1088/0031-9155/54/4/005
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发表时间：
2009-02-21
影响因子：
3.5
通讯作者：
Kazanzides P
中科院分区：
文献类型：
--
作者：
Matinfar M;Ford E;Iordachita I;Wong J;Kazanzides P
小动物研究可以对生物过程、疾病进展和治疗反应进行详细研究，有可能为临床环境提供一座天然的桥梁。小动物辐射研究平台(SARRP)是一种便携式系统，可在机载锥束CT(CBCT)引导下进行精确照射，射束尺寸低至约0.5毫米，并可进行最佳计划的照射。本文主要研究高精度辐照系统的几何标定问题。提出了一种新的治疗光束定标技术，该技术使用了一台不需要知道精确定位的X射线相机。使用相机系统，我们获得了用于门架校准的数字重建的3D星形镜头，然后开发了一种技术，将每个光束与机器人动物定位平台的公共等中心对准。该校准结合了锥束CT引导的定位。未校正的波束相对于校准原点的偏移量范围为0.4 mm至5.2 mm。通过校正，这些对准可以控制在1 mm以内。该校准技术被用于对由EBT Gafchroic薄膜构建的体模进行类似于立体定向的弧光处理。使用0.5 mm的准直光束，所有的光束都与大约1.07 mm的测量光束(FWHM)在共同的等中心相交。SARRP的期望定位精度为0.25 mm，结果表明定位精度为0.2 mm。为了充分实现SARRP的辐射定位能力，就像任何这样的系统一样，需要精确的几何校准。本文介绍的基于X射线相机的技术为系统校准提供了一种直接和半自动的方法。
Small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The Small Animal Radiation Research Platform (SARRP) is a portable system for precision irradiation with beam sizes down to approximately 0.5 mm and optimally planned radiation with on-board cone-beam CT (CBCT) guidance. This paper focuses on the geometric calibration of the system for high-precision irradiation. A novel technique for calibration of the treatment beam is presented, which employs an x-ray camera whose precise positioning need not be known. Using the camera system we acquired a digitally reconstructed 3D “star shot” for gantry calibration, and then developed a technique to align each beam to a common isocenter with the robotic animal positioning stages. The calibration incorporates localization by cone-beam CT guidance. Uncorrected offsets of the beams with respect to the calibration origin ranged from 0.4 mm to 5.2 mm. With corrections, these alignments can be brought to within < 1 mm. The calibration technique was used to deliver a stereotactic-like arc treatment to a phantom constructed with EBT Gafchromic films. All beams were shown to intersect at a common isocenter with a measured beam (FWHM) of approximately 1.07 mm using the 0.5 mm collimated beam. The desired positioning accuracy of the SARRP is 0.25 mm and the results indicate an accuracy of 0.2 mm. To fully realize the radiation localization capabilities of the SARRP, precise geometric calibration is required, as with any such system. The x-ray camera-based technique presented here provides a straightforward and semi-automatic method for system calibration.
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影响因子：
3.8
作者：
Graves, Edward E.;Zhou, Hu;Boyer, Arthur L.
通讯作者：
Boyer, Arthur L.
DOI：
10.1109/70.538972
发表时间：
1996-10-01
期刊：
IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION
影响因子：
--
作者：
Hutchinson, S;Hager, GD;Corke, PI
通讯作者：
Corke, PI
影响因子：
3.8
作者：
Stojadinovic, S.;Low, D. A.;Grigsby, P. W.
通讯作者：
Grigsby, P. W.
影响因子：
3
作者：
Rubins, DJ;Meadors, AK;Cherry, SR
通讯作者：
Cherry, SR
影响因子：
2.9
作者：
Turnbull, DH;Ramsay, JA;Foster, FS
通讯作者：
Foster, FS