Isocyanate-terminated urethane-based dental adhesive bridges dentinal matrix collagen with adhesive resin.
Isocyanate-terminated urethane-based dental adhesive bridges dentinal matrix collagen with adhesive resin.
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异氰酸酯封端的聚氨酯基牙科粘合剂将牙本质基质胶原蛋白与粘合树脂桥接起来。
DOI：
10.1016/j.actbio.2018.11.007
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发表时间：
2019
影响因子：
9.7
通讯作者：
Chen Jihua
中科院分区：
文献类型：
--
作者：
Xu Rongchen;Yu Fan;Huang Li;Zhou Wei;Wang Yan;Wang Fu;Sun Xiang;Chang Gang;Fang Ming;Zhang Ling;Li Fang;Tay Franklin;Niu Lina;Chen Jihua
市售的牙科粘合剂不能在树脂-牙本质界面内化学结合脱矿胶原基质与牙本质材料。胶原纤维和聚合树脂之间的亚微米分离为粘合劣化提供了背景。在这里，新的异氰酸酯封端的聚氨酯甲基丙烯酸酯前体（UMP）的合成能力，通过共价键和氢键化学键合到牙本质胶原。与UMP接枝的胶原蛋白还与其他甲基丙烯酸酯树脂单体共聚，从而产生化学连接的生物复合材料的单块。UMP的粘度、转化度和生物相容性与市售树脂单体相当。含40%UMP的实验粘合剂表现出共聚能力，良好的渗透能力，并实现比对照市售粘合剂更高的牙本质即时粘结强度。通过将UMP加入到牙本质粘合剂中来改善牙本质粘合，证明了未来评估这些基于UMP的粘合剂在延长树脂-牙本质粘合剂的寿命方面的潜力是合理的。而这些粘合剂不能与胶原化学结合，破坏了结合质量。本研究描述了一种新型的异氰酸酯封端的聚氨酯多甲基丙烯酸酯前体（UMP），它可以通过共价键和氢键将牙本质基质胶原与粘接树脂连接起来。此外，实验的UMP基粘合剂显示出更好的共聚能力，良好的渗透能力和更高的即时粘结强度比pupper-effective粘合剂Single Bond 2。基于UMP的新的化学键合机制理论上会产生更稳定的键合界面，更耐降解。
Commercially available dental adhesives fail to chemically unite the demineralized collagen matrix with resinous materials within the resin-dentin interface. Sub-micron separations between the collagen fibrils and polymerized resin provide the backdrop for bond deterioration. Here, novel isocyanate-terminated urethane methacrylate precursors (UMP) were synthesized with the capacity to bond chemically to dentin collagen via covalent and hydrogen bonds. Collagen grafted with UMP also copolymerized with other methacrylate resin monomers, thereby producing a monoblock of chemically-linked biocomposite. The viscosity, degree of conversion and biocompatibility of UMP are comparable with commercially available resin monomers. An experimental adhesive containing 40% UMP demonstrated co-polymerization capability, good infiltration capacity and achieved higher immediate bond strength to dentin than the control commercially available adhesive. Improvement of dentin bonding by incorporation of UMP into dentin adhesives justifies future evaluation of the potential of these UMP-based adhesives in extending the longevity of resin-dentin bonds.Statement of SignificanceComposite-adhesive restorations have become an indispensable treatment modality in contemporary restorative dentistry. While the inability of these adhesives to bond chemically with collagen undermines the bond quality. This study describes a novel isocyanate-terminated urethane multi methacrylate precursors (UMP) which can bridge dentinal matrix collagen with adhesive resin by covalent and hydrogen bonds. Furthermore, an experimental UMP-based adhesive shows better co-polymerization capability, good infiltration capacity and higher immediate bond strength than the putatively effective adhesive Single Bond 2. The new chemical bonding mechanism based on UMP would theoretically produce more stable bonding interface that are more resistant to degradation.
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影响因子：
6
作者：
T. Vieira;J. Silva;J. Borges;C. Henriques
通讯作者：
T. Vieira;J. Silva;J. Borges;C. Henriques
影响因子：
--
作者：
Melnik I;Mnouskin Y;Verdiger Kurzbart E;Yoffe B
通讯作者：
Yoffe B
影响因子：
5
作者：
Manojlovic, Dragica;Radisic, Marina;Miletic, Vesna
通讯作者：
Miletic, Vesna
影响因子：
2.2
作者：
S. Armstrong;M. Vargas;I. Chung;D. Pashley;J. Campbell;J. Laffoon;F. Qian
通讯作者：
S. Armstrong;M. Vargas;I. Chung;D. Pashley;J. Campbell;J. Laffoon;F. Qian
影响因子：
9.7
作者：
Chang, Hsiao-Hua;Chang, Mei-Chi;Jeng, Jiiang-Huei
通讯作者：
Jeng, Jiiang-Huei