Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging.
Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging.
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用于评估和治疗卵巢衰老的生物材料和先进技术
DOI：
10.1186/s12951-022-01566-8
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发表时间：
2022-08-11
影响因子：
10.2
通讯作者：
Wang, Shixuan
中科院分区：
文献类型：
--
作者：
Wu, Meng;Guo, Yican;Wei, Simin;Xue, Liru;Tang, Weicheng;Chen, Dan;Xiong, Jiaqiang;Huang, Yibao;Fu, Fangfang;Wu, Chuqing;Chen, Ying;Zhou, Su;Zhang, Jinjin;Li, Yan;Wang, Wenwen;Dai, Jun;Wang, Shixuan
卵巢衰老的特征是卵巢功能的进行性下降。随着世界范围内预期寿命的延长，卵巢老化已逐渐成为女性的一个关键健康问题。多年来，人们开发了各种策略来保护女性的生育能力，但目前还没有临床治疗方法来延缓卵巢衰老。最近，生物材料和技术的进步，如三维(3D)打印和微流控技术，用于包裹卵泡和纳米颗粒作为药物输送系统，已显示出潜在的翻译策略来解决卵巢衰老问题。本文介绍了卵巢衰老机制的研究进展，综述了生物材料在评价和治疗卵巢衰老方面的现状，包括安全性、潜在的应用、未来的发展方向和翻译上的困难。
Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation.
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DOI：
10.1530/jrf.0.0800509
发表时间：
1987-07-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
BEZARD, J;VIGIER, B;JOSSO, N
通讯作者：
JOSSO, N
影响因子：
6.1
作者：
Anderiesz, C;Fong, CY;Trounson, AO
通讯作者：
Trounson, AO
影响因子：
4.8
作者：
Boyle CP;Raji CA;Erickson KI;Lopez OL;Becker JT;Gach HM;Kuller LH;Longstreth W Jr;Carmichael OT;Riedel BC;Thompson PM
通讯作者：
Thompson PM
DOI：
10.1530/rep-16-0129
发表时间：
2016-09
期刊：
Reproduction (Cambridge, England)
影响因子：
--
作者：
Briley SM;Jasti S;McCracken JM;Hornick JE;Fegley B;Pritchard MT;Duncan FE
通讯作者：
Duncan FE
影响因子：
4.4
作者：
Bittles, Alan H.;Bower, Carol;Glasson, Emma J.
通讯作者：
Glasson, Emma J.