Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System.
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System.
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DOI：
10.1016/j.tins.2021.02.001
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发表时间：
2021-06
影响因子：
15.9
通讯作者：
Tonini R
中科院分区：
文献类型：
--
作者：
Peters KZ;Cheer JF;Tonini R
多巴胺、5-羟色胺和内源性大麻素是关键的神经调质，参与动机行为的许多方面，包括奖励处理、强化学习和行为灵活性。关于这些神经调质之间可能的关系的长期观点之一是多巴胺和血清素作为对手的想法。这一观点受到了新出现的证据的挑战，即血清素通过激活腹侧被盖区的多巴胺神经元来支持奖赏寻求。这些相互作用增加了额外的复杂性，内源性大麻素系统独特地影响多巴胺能和多巴胺能神经传递。在这篇综述中，我们讨论了这三个神经调节系统如何在细胞和电路水平上相互作用。促进精确识别和控制遗传靶向神经元群体的技术进步将有助于更好地理解这些基本系统之间的复杂关系，以及动机行为的潜在相关性。
Dopamine, serotonin and endocannabinoids are key neuromodulators involved in many aspects of motivated behavior, including reward processing, reinforcement learning and behavioral flexibility. Among the longstanding views about possible relationships between these neuromodulators, is the idea of dopamine and serotonin acting as opponents. This view has been challenged by emerging evidence that serotonin support reward seeking via activation of dopamine neurons in the ventral tegmental area. Adding an extra layer of complexity to these interactions, the endocannabinoid system is uniquely placed to influence dopaminergic and serotonergic neurotransmisison. In this review, we discuss how these three neuromodulatory systems interact at cellular and circuit levels. Technological advances that facilitate precise identification and control of genetically targeted neuronal populations will help achieve a better understanding of the complex relationship between these essential systems, and the potential relevance for motivated behavior.
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